Serum leptin concentrations in endometriosis

Paola Viganò, Edgardo Somigliana, Roberta Matrone, Antonella Dubini, Carlos Barron, Mario Vignali, Anna Maria Di Blasio

Research output: Contribution to journalArticle

Abstract

It has been recently reported that serum concentrations of the adipocyte-derived hormone leptin are increased in patients affected by endometriosis. On the basis of these findings, the present study was undertaken to evaluate whether the protein may be used as a new serum marker of the disease. A consecutive series of 67 reproductive-age women who underwent laparoscopy for benign gynecological pathologies were enrolled prospectively for the study. Serum leptin concentrations, as evaluated by a conventional RIA kit, were related to baseline clinical characteristics and surgical and histologic diagnosis. Endometriosis was documented in 42 women (stage I-II in 19 patients and stage III-IV in 23 patients). Twenty-five women of similar age and body mass index, who had no laparoscopic evidence of the disease, served as control group. Serum levels of leptin resulted similar between women without and with endometriosis at any stage (mean ± SEM, 12.5 ± 9.4 ng/ml and 12.1 ± 8.0 ng/ml, respectively). No significant association with leptin concentrations was observed in regard to stage of the disease, number of endometriotic implants, presence/absence of an endometriotic cyst or peritoneal deep endometriosis, and presence/absence of specific symptoms. Therefore, our results do not support the possibility to employ leptin measurement as a diagnostic tool for endometriosis. Further studies are needed to elucidate the relationship between leptin and endometrial system and determine the potential contribution of the molecule in implantation and early pregnancy development.

Original languageEnglish
Pages (from-to)1085-1087
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume87
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Endometriosis
Leptin
Serum
Laparoscopy
Pathology
Adipocytes
Cysts
Body Mass Index
Biomarkers
Hormones
Pregnancy
Control Groups
Scanning electron microscopy
Molecules
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum leptin concentrations in endometriosis. / Viganò, Paola; Somigliana, Edgardo; Matrone, Roberta; Dubini, Antonella; Barron, Carlos; Vignali, Mario; Di Blasio, Anna Maria.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 87, No. 3, 2002, p. 1085-1087.

Research output: Contribution to journalArticle

Viganò, Paola ; Somigliana, Edgardo ; Matrone, Roberta ; Dubini, Antonella ; Barron, Carlos ; Vignali, Mario ; Di Blasio, Anna Maria. / Serum leptin concentrations in endometriosis. In: Journal of Clinical Endocrinology and Metabolism. 2002 ; Vol. 87, No. 3. pp. 1085-1087.
@article{5feb4f9acb074428b1741410bb3038a9,
title = "Serum leptin concentrations in endometriosis",
abstract = "It has been recently reported that serum concentrations of the adipocyte-derived hormone leptin are increased in patients affected by endometriosis. On the basis of these findings, the present study was undertaken to evaluate whether the protein may be used as a new serum marker of the disease. A consecutive series of 67 reproductive-age women who underwent laparoscopy for benign gynecological pathologies were enrolled prospectively for the study. Serum leptin concentrations, as evaluated by a conventional RIA kit, were related to baseline clinical characteristics and surgical and histologic diagnosis. Endometriosis was documented in 42 women (stage I-II in 19 patients and stage III-IV in 23 patients). Twenty-five women of similar age and body mass index, who had no laparoscopic evidence of the disease, served as control group. Serum levels of leptin resulted similar between women without and with endometriosis at any stage (mean ± SEM, 12.5 ± 9.4 ng/ml and 12.1 ± 8.0 ng/ml, respectively). No significant association with leptin concentrations was observed in regard to stage of the disease, number of endometriotic implants, presence/absence of an endometriotic cyst or peritoneal deep endometriosis, and presence/absence of specific symptoms. Therefore, our results do not support the possibility to employ leptin measurement as a diagnostic tool for endometriosis. Further studies are needed to elucidate the relationship between leptin and endometrial system and determine the potential contribution of the molecule in implantation and early pregnancy development.",
author = "Paola Vigan{\`o} and Edgardo Somigliana and Roberta Matrone and Antonella Dubini and Carlos Barron and Mario Vignali and {Di Blasio}, {Anna Maria}",
year = "2002",
doi = "10.1210/jc.87.3.1085",
language = "English",
volume = "87",
pages = "1085--1087",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Serum leptin concentrations in endometriosis

AU - Viganò, Paola

AU - Somigliana, Edgardo

AU - Matrone, Roberta

AU - Dubini, Antonella

AU - Barron, Carlos

AU - Vignali, Mario

AU - Di Blasio, Anna Maria

PY - 2002

Y1 - 2002

N2 - It has been recently reported that serum concentrations of the adipocyte-derived hormone leptin are increased in patients affected by endometriosis. On the basis of these findings, the present study was undertaken to evaluate whether the protein may be used as a new serum marker of the disease. A consecutive series of 67 reproductive-age women who underwent laparoscopy for benign gynecological pathologies were enrolled prospectively for the study. Serum leptin concentrations, as evaluated by a conventional RIA kit, were related to baseline clinical characteristics and surgical and histologic diagnosis. Endometriosis was documented in 42 women (stage I-II in 19 patients and stage III-IV in 23 patients). Twenty-five women of similar age and body mass index, who had no laparoscopic evidence of the disease, served as control group. Serum levels of leptin resulted similar between women without and with endometriosis at any stage (mean ± SEM, 12.5 ± 9.4 ng/ml and 12.1 ± 8.0 ng/ml, respectively). No significant association with leptin concentrations was observed in regard to stage of the disease, number of endometriotic implants, presence/absence of an endometriotic cyst or peritoneal deep endometriosis, and presence/absence of specific symptoms. Therefore, our results do not support the possibility to employ leptin measurement as a diagnostic tool for endometriosis. Further studies are needed to elucidate the relationship between leptin and endometrial system and determine the potential contribution of the molecule in implantation and early pregnancy development.

AB - It has been recently reported that serum concentrations of the adipocyte-derived hormone leptin are increased in patients affected by endometriosis. On the basis of these findings, the present study was undertaken to evaluate whether the protein may be used as a new serum marker of the disease. A consecutive series of 67 reproductive-age women who underwent laparoscopy for benign gynecological pathologies were enrolled prospectively for the study. Serum leptin concentrations, as evaluated by a conventional RIA kit, were related to baseline clinical characteristics and surgical and histologic diagnosis. Endometriosis was documented in 42 women (stage I-II in 19 patients and stage III-IV in 23 patients). Twenty-five women of similar age and body mass index, who had no laparoscopic evidence of the disease, served as control group. Serum levels of leptin resulted similar between women without and with endometriosis at any stage (mean ± SEM, 12.5 ± 9.4 ng/ml and 12.1 ± 8.0 ng/ml, respectively). No significant association with leptin concentrations was observed in regard to stage of the disease, number of endometriotic implants, presence/absence of an endometriotic cyst or peritoneal deep endometriosis, and presence/absence of specific symptoms. Therefore, our results do not support the possibility to employ leptin measurement as a diagnostic tool for endometriosis. Further studies are needed to elucidate the relationship between leptin and endometrial system and determine the potential contribution of the molecule in implantation and early pregnancy development.

UR - http://www.scopus.com/inward/record.url?scp=0036962104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036962104&partnerID=8YFLogxK

U2 - 10.1210/jc.87.3.1085

DO - 10.1210/jc.87.3.1085

M3 - Article

C2 - 11889169

AN - SCOPUS:0036962104

VL - 87

SP - 1085

EP - 1087

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -