Serum levels of γ-glutamyltransferase and progression of coronary atherosclerosis

Giampaolo Niccoli, Roberta Della Bona, Nicola Cosentino, Domenico D'Amario, Flavia Belloni, Maria G. Conti, Massimo Gustapane, Francesco Fracassi, Luigi M. Biasucci, Elena Falcioni, Roberta Antonazzo Panico, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Background Progression of coronary atherosclerosis (ATS) has clinical implications. Serum levels of c-glutamyltransferase (GGT), a marker of oxidative stress, predict the risk of cardiovascular events. However, the role of GGT levels in the progression of coronary ATS has never been established. Materials and methods Consecutive patients undergoing two coronary angiographies (CAs) separated by at least 6 months were prospectively enrolled between May 2008 and June 2010. All patients were discharged on statins after the first CA. The severity and extent of coronary ATS were graded according to Bogaty's score, and the variation (δ) in stenosis score and extent index between follow-up (S2 and E2) and basal values (S1 and E1) were calculated. Predictors of δS2-1 and δE2-1 were assessed among clinical and laboratory data, including GGT levels, analyzed as δ between follow-up and basal values (δGGT2-1). Results We enrolled 100 consecutive patients (age 64±11 years, 68% men). Compliance with statin therapy was 100%. At multiple regression analysis, δGGT2-1 was the only independent predictor of δS2-1 (B = 0.18, SE= 0.07, P= 0.05), with δlow-density lipoprotein-cholesterol2-1 levels being of borderline statistical significance (P =0.07). On multiple regression analysis, δGGT2-1 was the only independent predictor of δE 2-1 (B= 0.32; SE= 0.11; P = 0.04), with active smoking habit and δfibrinogen2-1 levels being of borderline statistical significance (P = 0.08 and 0.06, respectively). Conclusion δGGT 2-1 is associated with angiographic coronary ATS progression in patients with ischemic heart disease on statin treatment, suggesting that oxidative stress may be another therapeutic target for preventing ATS progression beyond that of lipid-lowering therapies..

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalCoronary Artery Disease
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • atherosclerosis progression
  • c-glutamyltransferase
  • coronary angiography
  • coronary atherosclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Niccoli, G., Della Bona, R., Cosentino, N., D'Amario, D., Belloni, F., Conti, M. G., Gustapane, M., Fracassi, F., Biasucci, L. M., Falcioni, E., Antonazzo Panico, R., & Crea, F. (2013). Serum levels of γ-glutamyltransferase and progression of coronary atherosclerosis. Coronary Artery Disease, 24(1), 40-47. https://doi.org/10.1097/MCA.0b013e32835bbe6e