Serum levels of angiogenic cytokines decrease after radiotherapy in non-Hodgkin lymphomas

Roberto Ria, Teresa Cirulli, Teresa Giannini, Santa Bambace, Gabriella Serio, Maurizio Portaluri, Domenico Ribatti, Angelo Vacca, Franco Dammacco

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Serum levels of angiogenic cytokines decrease after radiotherapy in patients with cancer, and this may be relevant for treatment response and progression-free survival. Herein, we set out to determine whether circulating fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF) and platelet-derived growth factor-β (PDGF-β) decrease after radiotherapy in patients with non-Hodgkin lymphomas (NHLs) and if so, whether their decrease correlates with age, tumour histotype and stage, and radiation dose. Material and methods: The serum levels of FGF-2, VEGF, HGF and PDGF-β were evaluated before and after radiotherapy by an enzyme-linked immunosorbent assay (ELISA). These levels were correlated both reciprocally and with age, histotype, stage and radiation dose. Results: After radiotherapy, FGF-2, VEGF and PDGF-β, but not HGF, significantly decreased in relation to the radiation dose and response. No correlation was established between cytokine levels, except for VEGF and PDGF-β, which decreased in parallel. Haemoglobin levels did not decrease after radiotherapy, while FGF-2, VEGF, HGF and PDGF-β levels did not correlate with age, NHL stage and histotype. Conclusions: Soluble FGF-2, VEGF and PDGF-β levels decline after radiotherapy in NHLs, and may have predictive significance for response to treatment and recurrence.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalClinical and Experimental Medicine
Volume8
Issue number3
DOIs
Publication statusPublished - Sep 2008

Keywords

  • Angiogenesis
  • Cytokines
  • Non-Hodgkin lymphoma
  • Prognosis
  • Radiotherapy

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry

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