Serum levels of carbamazepine and cortical excitability by magnetic brain stimulation

M. Turazzini, P. Manganotti, R. Del Colle, M. Silvestri, A. Fiaschi

Research output: Contribution to journalArticle

Abstract

We investigated the correlation between serum levels of carbamazepine (CBZ) and motor excitability studied by different parameters of transcranial magnetic stimulation (TMS) in patients at the beginning of antiepileptic treatment. A total of 10 patients with complex partial seizures following stroke were treated with loading doses of CBZ. Motor evoked potential (MEP) was recorded from the thenar eminence (TE) muscles of the unaffected arm. In all patients, we studied rest and active motor threshold (rMT, aMT), MEP amplitude and cortical silent period (CSP). In three patients, intracortical inhibition (ICI) and intracortical facilitation (ICF) were measured using paired TMS at short interstimulus intervals (1-25 ms). The recording sessions were performed before treatment and after 7, 15 and 60 days (SD=16 days). Serum level of CBZ were monitored at each recording session. We observed a progressive increase in rMT and aMT until the serum levels of CBZ reached a steady state condition. No significant changes were observed in MEP amplitude, CSP, ICI and ICF. This study documents the increase of both motor threshold and drug serum levels in patients treated with loading doses of CBZ, suggesting a relationship between drug metabolism and the effect on motor cortical excitability.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalNeurological Sciences
Volume25
Issue number2
Publication statusPublished - Jun 2004

Fingerprint

Carbamazepine
Motor Evoked Potentials
Brain
Serum
Transcranial Magnetic Stimulation
Anticonvulsants
Seizures
Stroke
Cortical Excitability
Muscles
Therapeutics
Pharmaceutical Preparations

Keywords

  • Carbamazepine
  • Epilepsy
  • Stroke
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Turazzini, M., Manganotti, P., Del Colle, R., Silvestri, M., & Fiaschi, A. (2004). Serum levels of carbamazepine and cortical excitability by magnetic brain stimulation. Neurological Sciences, 25(2), 83-90.

Serum levels of carbamazepine and cortical excitability by magnetic brain stimulation. / Turazzini, M.; Manganotti, P.; Del Colle, R.; Silvestri, M.; Fiaschi, A.

In: Neurological Sciences, Vol. 25, No. 2, 06.2004, p. 83-90.

Research output: Contribution to journalArticle

Turazzini, M, Manganotti, P, Del Colle, R, Silvestri, M & Fiaschi, A 2004, 'Serum levels of carbamazepine and cortical excitability by magnetic brain stimulation', Neurological Sciences, vol. 25, no. 2, pp. 83-90.
Turazzini M, Manganotti P, Del Colle R, Silvestri M, Fiaschi A. Serum levels of carbamazepine and cortical excitability by magnetic brain stimulation. Neurological Sciences. 2004 Jun;25(2):83-90.
Turazzini, M. ; Manganotti, P. ; Del Colle, R. ; Silvestri, M. ; Fiaschi, A. / Serum levels of carbamazepine and cortical excitability by magnetic brain stimulation. In: Neurological Sciences. 2004 ; Vol. 25, No. 2. pp. 83-90.
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