Serum levels of fatty acid synthase in colorectal cancer patients are associated with tumor stage

Maria Notarnicola, Valeria Tutino, Menotti Calvani, Dionigi Lorusso, Vito Guerra, Maria Gabriella Caruso

Research output: Contribution to journalArticle

Abstract

Purpose: Fatty acid synthase is a common phenotype to various human cancers including those of prostate, colon, lung, endometrium, and stomach. Increased fatty acid synthase levels have been detected in serum from patients with breast and pancreatic cancer. In this study, serum levels of fatty acid synthase were measured in colorectal cancer patients at different stages of disease. Methods: Consecutive 67 patients with colorectal cancer were enrolled in the study. Serum levels of fatty acid synthase were examined by ELISA test. The Kruskal-Wallis test and the Χ2 method for trend have been used to analyze data. Results: Serumfatty acid synthase levels of patients belonging to three groups of stage disease are statistically different. The patients with stage III and IV have significantly higher serum levels of fatty acid synthase than patients with stage I-II. There is a positive trend in serum fatty acid synthase levels from stage I-II to stage III and IVof disease. Conclusions: Fatty acid synthase levels are associated with the stage of disease in patients with colorectal cancer.

Original languageEnglish
Pages (from-to)508-511
Number of pages4
JournalJournal of Gastrointestinal Cancer
Volume43
Issue number3
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Colon cancer
  • Fatty acid synthase
  • Lipogenic enzyme
  • Metastases

ASJC Scopus subject areas

  • Gastroenterology
  • Oncology

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