Serum levels of galectin-3 and its ligand 90k/mac-2bp in colorectal cancer patients

Palma A. Iacovazzi, Maria Notarnicola, Maria G. Caruso, Vito Guerra, Silvia Frisullo, Donato F. Altomare, Mario Correale

Research output: Contribution to journalArticlepeer-review

Abstract

Galectin-3 is an endogenous lectin that binds glycan epitopes of cell membrane and some extracellular glycoproteins such as integrins and laminin. Galectin-3 is involved in several biological activities including regulation of cellular cycle, modulation of adhesion and tumor progression and metastasis. 90K/Mac-2BP glycoprotein is also a serum galectin-3 ligand. 90K is able to modulate the immune reaction against tumors and viruses and its level increases in sera of several neoplastic diseases. In our study, we have evaluated levels of both glycoproteins in sera of non metastatic colon cancer patients. Interestingly, galectin-3 ranged higher in cancer patients than in controls (p

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalImmunopharmacology and Immunotoxicology
Volume32
Issue number1
DOIs
Publication statusPublished - Mar 2010

Keywords

  • 90K/Mac-2BP
  • Colorectal cancer
  • Galectin-3
  • Lectins
  • Tumor marker

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology

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