Abstract
Galectin-3 is an endogenous lectin that binds glycan epitopes of cell membrane and some extracellular glycoproteins such as integrins and laminin. Galectin-3 is involved in several biological activities including regulation of cellular cycle, modulation of adhesion and tumor progression and metastasis. 90K/Mac-2BP glycoprotein is also a serum galectin-3 ligand. 90K is able to modulate the immune reaction against tumors and viruses and its level increases in sera of several neoplastic diseases. In our study, we have evaluated levels of both glycoproteins in sera of non metastatic colon cancer patients. Interestingly, galectin-3 ranged higher in cancer patients than in controls (p
Original language | English |
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Pages (from-to) | 160-164 |
Number of pages | 5 |
Journal | Immunopharmacology and Immunotoxicology |
Volume | 32 |
Issue number | 1 |
DOIs | |
Publication status | Published - Mar 2010 |
Keywords
- 90K/Mac-2BP
- Colorectal cancer
- Galectin-3
- Lectins
- Tumor marker
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pharmacology
- Toxicology