Serum levels of galectin-3 and its ligand 90k/mac-2bp in colorectal cancer patients

Palma A. Iacovazzi; Maria Notarnicola; Maria G. Caruso; Vito Guerra; Silvia Frisullo; Donato F. Altomare; Mario Correale

doi:10.3109/08923970902936880

Serum levels of galectin-3 and its ligand 90k/mac-2bp in colorectal cancer patients

Palma A. Iacovazzi, Maria Notarnicola, Maria G. Caruso, Vito Guerra, Silvia Frisullo, Donato F. Altomare, Mario Correale

Ente Ospedaliero Specializzato in Gastroenterologia "Saverio de Bellis"

Research output: Contribution to journal › Article › peer-review

Abstract

Galectin-3 is an endogenous lectin that binds glycan epitopes of cell membrane and some extracellular glycoproteins such as integrins and laminin. Galectin-3 is involved in several biological activities including regulation of cellular cycle, modulation of adhesion and tumor progression and metastasis. 90K/Mac-2BP glycoprotein is also a serum galectin-3 ligand. 90K is able to modulate the immune reaction against tumors and viruses and its level increases in sera of several neoplastic diseases. In our study, we have evaluated levels of both glycoproteins in sera of non metastatic colon cancer patients. Interestingly, galectin-3 ranged higher in cancer patients than in controls (p

Original language	English
Pages (from-to)	160-164
Number of pages	5
Journal	Immunopharmacology and Immunotoxicology
Volume	32
Issue number	1
DOIs	https://doi.org/10.3109/08923970902936880
Publication status	Published - Mar 2010

Keywords

90K/Mac-2BP
Colorectal cancer
Galectin-3
Lectins
Tumor marker

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Pharmacology
Toxicology

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10.3109/08923970902936880

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abstract = "Galectin-3 is an endogenous lectin that binds glycan epitopes of cell membrane and some extracellular glycoproteins such as integrins and laminin. Galectin-3 is involved in several biological activities including regulation of cellular cycle, modulation of adhesion and tumor progression and metastasis. 90K/Mac-2BP glycoprotein is also a serum galectin-3 ligand. 90K is able to modulate the immune reaction against tumors and viruses and its level increases in sera of several neoplastic diseases. In our study, we have evaluated levels of both glycoproteins in sera of non metastatic colon cancer patients. Interestingly, galectin-3 ranged higher in cancer patients than in controls (p",

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AU - Iacovazzi, Palma A.

AU - Notarnicola, Maria

AU - Caruso, Maria G.

AU - Guerra, Vito

AU - Frisullo, Silvia

AU - Altomare, Donato F.

AU - Correale, Mario

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Serum levels of galectin-3 and its ligand 90k/mac-2bp in colorectal cancer patients

Abstract

Keywords

ASJC Scopus subject areas

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