Serum levels of intercellular adhesion molecule 1 in patients with HIV-related kaposi’s sarcoma

P. De Paoli, C. Caffau, M. D’Andrea, M. Tavio, U. Tirelli, G. Santini

Research output: Contribution to journalArticlepeer-review

Abstract

Infection with the human immunodeficiency virus type 1 (HIV-1) in man is associated with an increase in the incidence of Kaposi’s sarcoma (KS). The biological and clinical characteristics of these patients differ from those of subjects with other HIV-associated diseases. Here we report that levels of serum-soluble intercellular adhesion molecule 1 (sICAM 1) are increased in HIV-1-positive patients with KS, but not in patients belonging to other CDC classification groups. KS patients with elevated levels of serum sICAM 1 had a significant lowering of CD4 cell counts during the follow-up period compared with those KS subjects whose sICAM 1 levels were only moderately higher. We suggest that increased sICAM 1 levels may have a pathogenetic role in the development of HIV-associated immunodeficiency in KS patients and may also be considered an important prognostic factor.

Original languageEnglish
Pages (from-to)695-699
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume7
Issue number7
Publication statusPublished - 1994

Keywords

  • CD4 lymphocytes
  • HIV
  • Intercellular adhesion molecule 1
  • Kaposi’s sarcoma

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Virology
  • Immunology and Allergy

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