Serum levels of malondialdehyde and 4-hydroxy-2,3-nonenal in patients affected by familial chronic nail candidiasis

S. Gangemi, A. Saija, P. L. Minciullo, A. Tomaino, F. Cimino, G. Bisignano, S. Briuglia, M. V. Merlino, B. Dallapiccola, D. C. Salpietro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Familial chronic nail candidiasis (FCNC.MIM 607644) is a rare disorder characterized by early onset infections caused by different species of Candida and restricted to the nails; this disorder is genetically associated with low serum concentration of intercellular adhesion molecule 1 (ICAM-1). Herein we report the evidence of high circulating levels of malondialdehyde (MDA) and 4-hydroxy-2,3-nonenal (HNE) in seven patients of a five-generation Italian family affected by FCNC.MIM 607644. The present data evidence, in these patients, an increase in circulating MDA and HNE levels. Only some merely speculative hypotheses may be suggested to explain the mechanisms subserving the oxidative stress condition observed in these genetically ICAM-1 deficient patients; however, one has to point out that a chronic oxidative stress condition could contribute to the development of concurrent pathological alterations in which an overproduction of free radicals may play a central role.

Original languageEnglish
Pages (from-to)601-603
Number of pages3
JournalInflammation Research
Volume53
Issue number11
DOIs
Publication statusPublished - Nov 2004

Fingerprint

Nails
Oxidative stress
Candidiasis
Intercellular Adhesion Molecule-1
Malondialdehyde
Candida
Oxidative Stress
Serum
Free Radicals
Infection
4-hydroxy-2-nonenal

Keywords

  • CMC
  • FCNC
  • HNE
  • MDA
  • Oxidative stress

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

Cite this

Gangemi, S., Saija, A., Minciullo, P. L., Tomaino, A., Cimino, F., Bisignano, G., ... Salpietro, D. C. (2004). Serum levels of malondialdehyde and 4-hydroxy-2,3-nonenal in patients affected by familial chronic nail candidiasis. Inflammation Research, 53(11), 601-603. https://doi.org/10.1007/s00011-004-1306-9

Serum levels of malondialdehyde and 4-hydroxy-2,3-nonenal in patients affected by familial chronic nail candidiasis. / Gangemi, S.; Saija, A.; Minciullo, P. L.; Tomaino, A.; Cimino, F.; Bisignano, G.; Briuglia, S.; Merlino, M. V.; Dallapiccola, B.; Salpietro, D. C.

In: Inflammation Research, Vol. 53, No. 11, 11.2004, p. 601-603.

Research output: Contribution to journalArticle

Gangemi, S, Saija, A, Minciullo, PL, Tomaino, A, Cimino, F, Bisignano, G, Briuglia, S, Merlino, MV, Dallapiccola, B & Salpietro, DC 2004, 'Serum levels of malondialdehyde and 4-hydroxy-2,3-nonenal in patients affected by familial chronic nail candidiasis', Inflammation Research, vol. 53, no. 11, pp. 601-603. https://doi.org/10.1007/s00011-004-1306-9
Gangemi, S. ; Saija, A. ; Minciullo, P. L. ; Tomaino, A. ; Cimino, F. ; Bisignano, G. ; Briuglia, S. ; Merlino, M. V. ; Dallapiccola, B. ; Salpietro, D. C. / Serum levels of malondialdehyde and 4-hydroxy-2,3-nonenal in patients affected by familial chronic nail candidiasis. In: Inflammation Research. 2004 ; Vol. 53, No. 11. pp. 601-603.
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