Circulating levels of soluble intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin were measured in 20 advanced cancer patients at different times during recombinant interleukin-2 immunotherapy. The concentration of all three molecules progressively increased as did the levels of circulating tumor necrosis factor-α (TNF-α), which is known to induce endothelial cell activation. A fair direct relationship (but not statistically significant) between the raised concentration of soluble cell adhesion molecules and TNF-α was observed. We suggest that elevated levels of soluble adhesion molecules and TNF-α in the blood of IL-2-treated patients may arise from a systemic inflammatory reaction producing endothelial cell activation.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine