Serum levels of soluble cell adhesion molecules (ICAM-1, VCAM-1, E-selectin) and of cytokine TNF-α increase during interleukin-2 therapy

C. Fortis, L. Galli, G. Consogno, G. Citterio, P. Matteucci, U. Scaglietti, E. Bucci

Research output: Contribution to journalArticle

Abstract

Circulating levels of soluble intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin were measured in 20 advanced cancer patients at different times during recombinant interleukin-2 immunotherapy. The concentration of all three molecules progressively increased as did the levels of circulating tumor necrosis factor-α (TNF-α), which is known to induce endothelial cell activation. A fair direct relationship (but not statistically significant) between the raised concentration of soluble cell adhesion molecules and TNF-α was observed. We suggest that elevated levels of soluble adhesion molecules and TNF-α in the blood of IL-2-treated patients may arise from a systemic inflammatory reaction producing endothelial cell activation.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalClinical Immunology and Immunopathology
Volume76
Issue number2
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

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