Livelli sierici del telopeptide carbossiterminale del collagene di tipo I (ICTP) in pazienti con alterata funzione tiroidea.

Translated title of the contribution: Serum levels of the carboxyterminal telopeptide of type I collagen in patients with thyroid disorders

A. Conti, M. Monzani, L. Persani, A. Sartorio

Research output: Contribution to journalArticle

Abstract

Serum carboxyterminal cross-linked telopeptide of type I collagen (ICTP) levels, marker of bone resorption, were evaluated in 35 patients with hyperthyroidism (age range: 21-68 years) and in 35 with hypothyroidism (age range: 28-69 years). Data obtained were compared with those recorded in an age and sex matched control group. In patients with hyperthyroidism, serum ICTP levels were significantly higher than in controls (mean +/- SE: 9.1 +/- 0.7 vs 4.1 +/- 0.3 ng/ml; p <0.0001). In patients with untreated hypothyroidism ICTP levels were significantly reduced (2.5 +/- 0.2 ng/ml, p <0.0001); seven patients with hypothyroidism, evaluated after substitutive L-thyroxine treatment, showed a significant increase of ICTP levels (6th month: 5.9 +/- 0.7 ng/ml, p <0.02). Taking into consideration all the data recorded in patients with both hyper- and hypothyroidism, serum ICTP levels were positively correlated with those of free T3 and free T4 and negatively correlated with those of TSH. In conclusion, our data show that repeated determinations of ICTP levels, which directly reflect the bone resorption activity, might be usefully employed in the evaluation of bone turnover in patients with thyroid disorders.

Original languageItalian
Pages (from-to)127-131
Number of pages5
JournalMinerva Endocrinologica
Volume19
Issue number3
Publication statusPublished - Sep 1994

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Thyroid Gland
Hypothyroidism
Hyperthyroidism
Bone Resorption
Serum
Bone Remodeling
Collagen Type I
Thyroxine
collagen type I trimeric cross-linked peptide
Research Design
Control Groups
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Livelli sierici del telopeptide carbossiterminale del collagene di tipo I (ICTP) in pazienti con alterata funzione tiroidea. / Conti, A.; Monzani, M.; Persani, L.; Sartorio, A.

In: Minerva Endocrinologica, Vol. 19, No. 3, 09.1994, p. 127-131.

Research output: Contribution to journalArticle

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