Serum levels of tumour necrosis factor alpha and other cytokines do not correlate with weight loss and anorexia in cancer patients

Marco Maltoni, Laura Fabbri, Oriana Nanni, Emanuela Scarpi, Laura Pezzi, Emanuela Flamini, Angela Riccobon, Stefania Derni, Gualtiero Pallotti, Dino Amadori

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer anorexia-cachexia syndrome (CACS), which is characterized by progressive weight loss (WL) and anorexia (A), is present in 51% of advanced cancer patients and in 80% of terminally ill cancer patients. One of the most controversial aspects of CACS is its oetiopathogenesis; experimental studies have identified certain cytokines [Tumour necrosis factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), and gamma interferon (γ-IFN)] as possible co-factors in the onset of the syndrome. The aim of our study was to investigate the correlation between serum levels of circulating cytokines and severity of CACS. The following series of parameters was indentified in 61 patients with advanced and terminal cancer: stage of disease; Karnofsky performance status (KPS) and clinical symptoms; biohumoral, anthropometric and immunological situation; level of circulating cytokines. All these parameters were evaluated for a possible link with WL/A. Our data do not show any significant correlation between circulating cytokines and WL/A. A direct correlation was identified between WL/A and nausea (P=0.03 and P

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalSupportive Care in Cancer
Volume5
Issue number2
DOIs
Publication statusPublished - Mar 1997

Keywords

  • Anorexia
  • Cachexia
  • Cancer
  • Interferon
  • Interleukin
  • tumour necrosis factor

ASJC Scopus subject areas

  • Oncology
  • Nursing(all)

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