Serum levels of vascular dysfunction markers reflect disease severity and stage in systemic sclerosis patients

Marta Cossu, Romina Andracco, Alessandro Santaniello, Maurizio Marchini, Adriana Severino, Monica Caronni, Timothy Radstake, Lorenzo Beretta

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective. To improve knowledge of vasculopathy in SSc through the assessment of serum levels of circulating angiogenetic and endothelial dysfunction markers in patients at different stages of the disease. Methods. Sera from 224 subjects were obtained and concentrations of angiopoietin-2, chemokine (C-X-C motif) ligand (CXCL)-16 (CXCL16), E-selectin, soluble intercellular adhesion molecule-1, IL-8 (CXCL8), soluble vascular adhesion molecule-1 and VEGF were determined by a Luminex assay. Subjects included healthy controls, 47 early SSc patients according to LeRoy and Medsger without other signs and symptoms of evolutive disease, 48 definitive SSc (defSSc) patients according to the 2013 ACR/EULAR criteria without skin or lung fibrosis, 51 lcSSc subjects and 35 dcSSc subjects. Results. The four groups of patients showed well-distinct clinical and laboratory characteristics, with a linear decreasing trend in forced vital capacity and diffusing capacity for carbon monoxide % predicted values from early SSc to defSSc to lcSSc and to dcSSc, and a linear increasing trend in ESR, and in the prevalence of abnormal CRP, serum gamma globulins and lung fibrosis (all P

Original languageEnglish
Article numberkew017
Pages (from-to)1112-1116
Number of pages5
JournalRheumatology
Volume55
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

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Systemic Scleroderma
Blood Vessels
Serum
Fibrosis
Angiopoietin-2
CXC Chemokines
Serum Globulins
Lung
E-Selectin
gamma-Globulins
Vital Capacity
Intercellular Adhesion Molecule-1
Carbon Monoxide
Interleukin-8
Vascular Endothelial Growth Factor A
Signs and Symptoms
Healthy Volunteers
Ligands
Skin

Keywords

  • Adhesion molecules
  • Angiogenesis
  • Early disease
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Serum levels of vascular dysfunction markers reflect disease severity and stage in systemic sclerosis patients. / Cossu, Marta; Andracco, Romina; Santaniello, Alessandro; Marchini, Maurizio; Severino, Adriana; Caronni, Monica; Radstake, Timothy; Beretta, Lorenzo.

In: Rheumatology, Vol. 55, No. 6, kew017, 01.06.2016, p. 1112-1116.

Research output: Contribution to journalArticle

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AU - Severino, Adriana

AU - Caronni, Monica

AU - Radstake, Timothy

AU - Beretta, Lorenzo

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