Serum markers for extracellular matrix components in the diagnosis of alcoholic hepatitis

G. Annoni, P. Lampertico, M. F. Donato, B. Khlat, M. Colombo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Prospective clinical studies have demonstrated that alcoholic hepatitis and not cirrhosis itself is the factor which determines the survival of patients with alcoholic disease. Since the only reliable method for diagnosing alcoholic hepatitis is liver histology, there is an urgent need for non-invasive biochemical tests that can be used to monitor patients at risk. Serum type III procollagen peptide (PIIIP) is a likely candidate, since the levels of this marker correlate with the degree of hepatic inflammation and necrosis in chronic liver diseases, including alcoholic liver diseases. We therefore studied whether serum PIIIP can also detect alcoholic hepatitis in alcohol abusers with different degrees of hepatic damage selected prospectively. For the same purpose, we also measured the serum levels of laminin (Lam-P1), a breakdown product of a major glycoprotein component of basement membranes. Both PIIIP and Lam-P1 values were high in the majority of 118 patients with liver damage. However, both the extracellular matrix markers were highest in those patients with alcoholic hepatitis superimposed on cirrhosis (PIIIP 50.4 ± 36.4 ng/ml vs. 8.1 ± 2.6 controls, P <0.01) (Lam-P1 4.50 ± 1.49 U/l vs. 1.24 ± 0.26 U/l controls, P <0.01) and less markedly elevated in patients with alcoholic hepatitis alone (PIIIP 23.5 ± 17.6 ng/ml, P <0.001) (Lam-P1 2.60 ± 1.09 U/l, P <0.01). Lam-P1, but not PIIIP, could differentiate between patients with cirrhosis and those with steato-fibrosis and patients with alcoholic hepatitis from those with steatofibrosis (2.12 ± 0.60 U/l, P <0.01) (1.42 ± 0.41 U/l, P <0.01). These data suggest that PIIIP and Lam-P1 are useful markers for detecting alcoholic hepatitis in patients at risk.

Original languageEnglish
Title of host publicationChronic liver damage: proceedings of the Annual Meeting of the Italian National Programme on Liver Cirrhosis. ICS910
EditorsM.U. Dianzani, P. Gentilini, M.U. Dianzani, P. Gentilini
PublisherElsevier Science Publishers B.V.
Pages171-180
Number of pages10
ISBN (Print)0444812113
Publication statusPublished - 1990
EventThe Annual Meeting of the Italian National Programme on Liver Cirrhosis -
Duration: Jan 11 1990Jan 13 1990

Other

OtherThe Annual Meeting of the Italian National Programme on Liver Cirrhosis
Period1/11/901/13/90

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Annoni, G., Lampertico, P., Donato, M. F., Khlat, B., & Colombo, M. (1990). Serum markers for extracellular matrix components in the diagnosis of alcoholic hepatitis. In M. U. Dianzani, P. Gentilini, M. U. Dianzani, & P. Gentilini (Eds.), Chronic liver damage: proceedings of the Annual Meeting of the Italian National Programme on Liver Cirrhosis. ICS910 (pp. 171-180). Elsevier Science Publishers B.V..