Serum markers of intrahepatic cholangiocarcinoma

Giulia Malaguarnera, Isabella Paladina, Maria Giordano, Michele Malaguarnera, Gaetano Bertino, Massimiliano Berretta

Research output: Contribution to journalArticlepeer-review

Abstract

Cholangiocarcinoma (CCA) is a relatively rare type of primary liver cancer that originates in the bile duct epithelium. It is an aggressive malignancy typified by unresponsiveness to chemotherapy and radiotherapy. Despite advances in radiologic techniques and laboratory diagnostic test, the diagnosis of CCA remains highly challenging. Development in molecular techniques has led to go into the possible use of serum markers in diagnosing of cholangiocarcinoma. This review summarizes the principal characteristics of serum markers of cholangiocarcinoma. The tumour markers used frequently such as Carbohydrate antigen 19-9 (CA 19-9), Carcinogenic Embryonic antigen (CEA), and Cancer Antigen 125 have shown sufficient sensitivity and specificity to detect and monitor CCA. In particular, the combination of these tumour markers seems to increase their efficiency in diagnosing of cholangiocarcinoma. New markers such as Soluble fragment of cytokeratin 19 (CYFRA 21-1) Mucins, Tumour Markers 2 pyruvate-Kinase (TuM 2-PK) and metalloproteinase-7 (MMP-7) have been recently shown to help in the diagnosis of CCA, with in some cases a prognostic value.

Original languageEnglish
Pages (from-to)219-228
Number of pages10
JournalDisease Markers
Volume34
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • CA 19-9
  • CEA
  • Cholangiocarcinoma
  • tumor markers

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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