Leukocyte migration-inhibitory activity (LIF) was found in the sera of 11/14 (78.5%) children with heterophil-positive infectious mononucleosis as opposed to only 1/15 (6.6%) control children (p <0.001). It is postulated that the cellular unresponsiveness observed during the acute phase of the infection may be partly explained by the production of an inhibitory factor(s) with LIF-like activity, possibly by a subpopulation of suppressor lymphocytes present in excessive concentrations in Epstein-Barr virus-infected patients.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine