Serum migration-inhibitory activity in children with acute infectious mononucleosis

A. Bertotto, Daniela Caprino, R. Vaccaro, Franca Sonaglia

Research output: Contribution to journalArticlepeer-review


Leukocyte migration-inhibitory activity (LIF) was found in the sera of 11/14 (78.5%) children with heterophil-positive infectious mononucleosis as opposed to only 1/15 (6.6%) control children (p <0.001). It is postulated that the cellular unresponsiveness observed during the acute phase of the infection may be partly explained by the production of an inhibitory factor(s) with LIF-like activity, possibly by a subpopulation of suppressor lymphocytes present in excessive concentrations in Epstein-Barr virus-infected patients.

Original languageEnglish
Pages (from-to)314-318
Number of pages5
JournalClinical Immunology and Immunopathology
Issue number3
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine


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