Serum migration-inhibitory activity in infants with respiratory syncytial virus bronchiolitis

A. Bertotto, G. Stagni, F. Sonaglia, D. Caprino, R. Vaccaro

Research output: Contribution to journalArticle

Abstract

Using an unidirectional leukocyte migration-inhibition (LMI) assay, we investigated the migration-inhibitory activity (LIF) in the sera of 25 infants who developed bronchiolitis following respiratory syncytial virus (RSV) infection. Blood samples for serum-LIF activity detection were obtained from patients the day after admission and two weeks later. The LMI assay revealed serum-LIF activity in 17 (68%) blood samples taken during the acute phase of the disease. In contrast, no inhibition was found in the convalescent blood samples with the exception of 5 (20%). This difference was statistically significant (χ 2 = 9.82; P

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume60
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Immunology

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    Bertotto, A., Stagni, G., Sonaglia, F., Caprino, D., & Vaccaro, R. (1981). Serum migration-inhibitory activity in infants with respiratory syncytial virus bronchiolitis. Bollettino dell'Istituto Sieroterapico Milanese, 60(2), 150-154.