Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

Giulio Disanto, Rocco Adiutori, Ruth Dobson, Vittorio Martinelli, Gloria Dalla Costa, Tessel Runia, Evgeniy Evdoshenko, Eric Thouvenot, Maria Trojano, Niklas Norgren, Charlotte Teunissen, Ludwig Kappos, Gavin Giovannoni, Jens Kuhle

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls. Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls. Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5×10-5 and OR=7.03; 95% CI 2.85 to 17.34; p=2.3×10-5, respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis. Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume87
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Intermediate Filaments
Light
Serum
Multiple Sclerosis
Biomarkers
Gadolinium
Syndrome
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

Cite this

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome. / Disanto, Giulio; Adiutori, Rocco; Dobson, Ruth; Martinelli, Vittorio; Costa, Gloria Dalla; Runia, Tessel; Evdoshenko, Evgeniy; Thouvenot, Eric; Trojano, Maria; Norgren, Niklas; Teunissen, Charlotte; Kappos, Ludwig; Giovannoni, Gavin; Kuhle, Jens.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 87, No. 2, 01.02.2016, p. 126-129.

Research output: Contribution to journalArticle

Disanto, G, Adiutori, R, Dobson, R, Martinelli, V, Costa, GD, Runia, T, Evdoshenko, E, Thouvenot, E, Trojano, M, Norgren, N, Teunissen, C, Kappos, L, Giovannoni, G & Kuhle, J 2016, 'Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome', Journal of Neurology, Neurosurgery and Psychiatry, vol. 87, no. 2, pp. 126-129. https://doi.org/10.1136/jnnp-2014-309690
Disanto, Giulio ; Adiutori, Rocco ; Dobson, Ruth ; Martinelli, Vittorio ; Costa, Gloria Dalla ; Runia, Tessel ; Evdoshenko, Evgeniy ; Thouvenot, Eric ; Trojano, Maria ; Norgren, Niklas ; Teunissen, Charlotte ; Kappos, Ludwig ; Giovannoni, Gavin ; Kuhle, Jens. / Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome. In: Journal of Neurology, Neurosurgery and Psychiatry. 2016 ; Vol. 87, No. 2. pp. 126-129.
@article{e6af399c52354f52aedf7bcf3e3d3c8f,
title = "Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome",
abstract = "Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls. Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls. Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95{\%} CI 2.63 to 13.02; p=1.5×10-5 and OR=7.03; 95{\%} CI 2.85 to 17.34; p=2.3×10-5, respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95{\%} CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95{\%} CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95{\%} CI 1.21 to 5.31; p=0.013) at CIS diagnosis. Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.",
author = "Giulio Disanto and Rocco Adiutori and Ruth Dobson and Vittorio Martinelli and Costa, {Gloria Dalla} and Tessel Runia and Evgeniy Evdoshenko and Eric Thouvenot and Maria Trojano and Niklas Norgren and Charlotte Teunissen and Ludwig Kappos and Gavin Giovannoni and Jens Kuhle",
year = "2016",
month = "2",
day = "1",
doi = "10.1136/jnnp-2014-309690",
language = "English",
volume = "87",
pages = "126--129",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

AU - Disanto, Giulio

AU - Adiutori, Rocco

AU - Dobson, Ruth

AU - Martinelli, Vittorio

AU - Costa, Gloria Dalla

AU - Runia, Tessel

AU - Evdoshenko, Evgeniy

AU - Thouvenot, Eric

AU - Trojano, Maria

AU - Norgren, Niklas

AU - Teunissen, Charlotte

AU - Kappos, Ludwig

AU - Giovannoni, Gavin

AU - Kuhle, Jens

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls. Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls. Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5×10-5 and OR=7.03; 95% CI 2.85 to 17.34; p=2.3×10-5, respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis. Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.

AB - Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls. Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls. Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5×10-5 and OR=7.03; 95% CI 2.85 to 17.34; p=2.3×10-5, respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis. Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.

UR - http://www.scopus.com/inward/record.url?scp=84958873094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958873094&partnerID=8YFLogxK

U2 - 10.1136/jnnp-2014-309690

DO - 10.1136/jnnp-2014-309690

M3 - Article

VL - 87

SP - 126

EP - 129

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 2

ER -