Serum NGF levels in children and adolescents with either Williams syndrome or Down syndrome

Gemma Calamandrei, Enrico Alleva, Francesca Cirulli, Armelle Queyras, Virginia Volterra, Olga Capirci, Stefano Vicari, Aldo Giannotti, Paolo Turrini, Luigi Aloe

Research output: Contribution to journalArticlepeer-review


The neurotrophin nerve growth factor (NGF) is a major regulator of peripheral and central nervous system development. Serum NGF was measured in normally developing control children (n=26) and in individuals affected by congenital syndromes associated with learning disability: either Williams syndrome (WS; n=12) or Down syndrome (DS; n=21). Participants were assessed at three distinct developmental stages: early childhood (2 to 6 years), childhood (8 to 12 years), and adolescence (14 to 20 years). A sample was taken only once from each individual. Serum NGF levels were markedly higher in participants with WS, than DS and control participants. In addition, different developmental profiles emerged in the three groups: while in normally developing individuals NGF levels were higher in early childhood than later on, children with WS showed constantly elevated NGF levels. When compared to control participants, those with DS showed lower NGF levels only during early childhood. Neuropsychological assessment confirmed previously reported differences among the three groups in the development of linguistic/cognitive abilities. Some features of individuals with WS, such as hyperacusis and hypertension, could be related to high-circulating NGF levels.

Original languageEnglish
Pages (from-to)746-750
Number of pages5
JournalDevelopmental Medicine and Child Neurology
Issue number11
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)


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