TY - JOUR
T1 - Serum NT-proBNP Levels Are Not Related to Vitamin D Status in Young Patients with Congenital Heart Defects
AU - Passeri, E.
AU - Rigolini, R.
AU - Costa, E.
AU - Verdelli, C.
AU - Arcidiacono, C.
AU - Carminati, M.
AU - Corbetta, S.
PY - 2016
Y1 - 2016
N2 - Context. Hypovitaminosis D frequently occurs in early life and increases with age. Vitamin D has been suggested to influence cardiac performance and N-terminal-pro-type B natriuretic peptide (NT-proBNP) release in adults with heart failure. Objectives. To assess the vitamin D status and the impact of hypovitaminosis D on circulating NT-proBNP levels in young patients with congenital heart defects (CHD). Design and Patients. This cross-sectional study included the assessment of serum 25-hydroxyvitamin D (25OHD), parathyroid function markers, and NT-proBNP levels in a series of 230 young in-patients (117 females, 113 males; 6.4 (4.0-9.1) years (median, interquartile range)) with CHD. Results. Serum 25OHD levels 30 ng/mL) occurred in 25% of patients. Serum 25OHD levels inversely correlated with age (r =-0.169, P = 0.013) and height standard deviation score (r =-0.269, P = 0.001). After correction for age, 25OHD negatively correlated with serum PTH levels (β =-0.200, P = 0.002). PTH levels above the upper quartile (44 pg/mL) occurred in 32% of hypovitaminosis D patients. Serum NT-proBNP levels were not correlated with 25OHD and PTH levels. Conclusions. Half of the young CHD patients were diagnosed with 25OHD deficiency and a third of hypovitaminosis D patients experienced hyperparathyroidism. Nonetheless, serum NT-proBNP levels were not associated with hypovitaminosis D as well as hyperparathyroidism.
AB - Context. Hypovitaminosis D frequently occurs in early life and increases with age. Vitamin D has been suggested to influence cardiac performance and N-terminal-pro-type B natriuretic peptide (NT-proBNP) release in adults with heart failure. Objectives. To assess the vitamin D status and the impact of hypovitaminosis D on circulating NT-proBNP levels in young patients with congenital heart defects (CHD). Design and Patients. This cross-sectional study included the assessment of serum 25-hydroxyvitamin D (25OHD), parathyroid function markers, and NT-proBNP levels in a series of 230 young in-patients (117 females, 113 males; 6.4 (4.0-9.1) years (median, interquartile range)) with CHD. Results. Serum 25OHD levels 30 ng/mL) occurred in 25% of patients. Serum 25OHD levels inversely correlated with age (r =-0.169, P = 0.013) and height standard deviation score (r =-0.269, P = 0.001). After correction for age, 25OHD negatively correlated with serum PTH levels (β =-0.200, P = 0.002). PTH levels above the upper quartile (44 pg/mL) occurred in 32% of hypovitaminosis D patients. Serum NT-proBNP levels were not correlated with 25OHD and PTH levels. Conclusions. Half of the young CHD patients were diagnosed with 25OHD deficiency and a third of hypovitaminosis D patients experienced hyperparathyroidism. Nonetheless, serum NT-proBNP levels were not associated with hypovitaminosis D as well as hyperparathyroidism.
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U2 - 10.1155/2016/3970284
DO - 10.1155/2016/3970284
M3 - Article
AN - SCOPUS:84959017540
VL - 2016
JO - Disease Markers
JF - Disease Markers
SN - 0278-0240
M1 - 3970284
ER -