Siero o plasma? Un quesito non nuovo che attende risposte nuove

Translated title of the contribution: Serum or plasma? An old question awaiting for new answers

Mario Plebani, Giuseppe Banfi, Sergio Bernardini, Francesco Bondanini, Laura Conti, Romolo Dorizzi, Fulvio Enrico Ferrara, Rita Mancini, Tommaso Trenti

Research output: Contribution to journalReview articlepeer-review


There is a continual debate on what type of sample a clinical laboratory should use. While serum is still considered the gold standard and remains the required sample matrix for some assays, laboratories must consider turn-around time, which is an important metric for laboratory performance and, more importantly, plays a critical role in patient care. In addition, a body of evidence emphasize the choice of plasma samples in order to prevent modifications of some measurands due to the coagulation process and related interferences. Advantages and disadvantages of serum and plasma are discussed on the basis of current literature and evidence. In addition, data are provided on the current utilization of the matrix (serum or plasma) in Italy and in other Countries. Finally, a rational for a possible shift from serum to plasma is provided.

Translated title of the contributionSerum or plasma? An old question awaiting for new answers
Original languageItalian
Pages (from-to)178-186
Number of pages9
JournalBiochimica Clinica
Issue number2
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical


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