Serum paraoxonase and arylesterase activities of paraoxonase-1 (PON-1), mild cognitive impairment, and 2-year conversion to dementia: A pilot study

Carlo Cervellati, Alessandro Trentini, Arianna Romani, Tiziana Bellini, Cristina Bosi, Beatrice Ortolani, Amedeo Zurlo, Angelina Passaro, Davide Seripa, Giovanni Zuliani

Research output: Contribution to journalArticle

Abstract

Converging lines of evidence suggest that paraoxonase-1 (PON-1) may confer protection against inflammatory and oxidative challenge which, in turn, plays a key-role in the onset and progression of dementia. The aim of this study was to evaluate whether serum PON-1 paraoxonase/arylesterase activities might predict the clinical conversion of mild cognitive impairment (MCI) to late-onset Alzheimer's disease (LOAD) or vascular dementia (VAD). Serum paraoxonase and arylesterase activities were measured by spectrophotometric assays at baseline in 141 MCI patients (median age: 77 years; interquartile range 71-81) and in 78 healthy controls (median age: 76 years; interquartile range 73-79). After 2 years of follow-up, 86 MCI remained stable (MCI/MCI), 34 converted to LOAD (MCI/LOAD), whereas 21 converted to VAD (MCI/VAD). Baseline arylesterase activity was lower in all MCI groups compared with controls (all p <0.01), whereas paraoxonase activity was lower in MCI/VAD group compared to controls (p <0.05) and MCI/MCI patients (p = 0.009). Low paraoxonase and arylesterase activities (I quartile) were associated to higher risk of conversion to VAD (OR: 3.74, 95% CI: 1.37-10.25 and OR: 3.16, 95% CI: 1.17-8.56, respectively). Our results suggest that in MCI patients low PON-1 activity might contribute to identify individuals susceptible to develop vascular dementia.

Original languageEnglish
Pages (from-to)395-401
Number of pages7
JournalJournal of Neurochemistry
Volume135
Issue number2
DOIs
Publication statusPublished - Oct 1 2015

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Keywords

  • Alzheimer's disease
  • arylesterase activity
  • mild cognitive impairment
  • paraoxonase activity
  • paraoxonase-1
  • vascular dementia

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Cervellati, C., Trentini, A., Romani, A., Bellini, T., Bosi, C., Ortolani, B., Zurlo, A., Passaro, A., Seripa, D., & Zuliani, G. (2015). Serum paraoxonase and arylesterase activities of paraoxonase-1 (PON-1), mild cognitive impairment, and 2-year conversion to dementia: A pilot study. Journal of Neurochemistry, 135(2), 395-401. https://doi.org/10.1111/jnc.13240