Serum pharmacokinetics in patients treated with transarterial chemoembolization (TACE) using two types of epirubicin-loaded microspheres

Cristina Sottani, Guido Poggi, Pietro Quaretti, Mario Regazzi, Benedetta Montagna, Erica Quaquarini, Marcello Imbriani, Emanuela Leoni, Pamela Di Cesare, Alberto Riccardi, Giovanni Bernardo, Claudio Minoia

Research output: Contribution to journalArticle

Abstract

Aim: The purpose of this study was the pharmacokinetic (PK) profile assessment in the serum of patients affected by hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) with drugeluting beads. Patients and Methods: This study included 20 patients, 12 treated with DC Bead® and 8 with HepaSphere Microsphere®, preloaded with epirubicin. No patient randomization was used for the inclusion in one group or in the other. Peripheral blood samples were obtained from all patients after the treatment, until 24 hours past the procedure. Results: The pharmacokinetic study showed low peak serum epirubicin concentrations with greater drug exposure for the DC Bead® group (p

Original languageEnglish
Pages (from-to)1769-1774
Number of pages6
JournalAnticancer Research
Volume32
Issue number5
Publication statusPublished - May 2012

Keywords

  • Epirubicin-loaded microspheres
  • Hepatocellular carcinoma
  • LC-ESI-MS/MS
  • Pharmacokinetic study
  • Transarterial chemo-embolization (TACE)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Sottani, C., Poggi, G., Quaretti, P., Regazzi, M., Montagna, B., Quaquarini, E., Imbriani, M., Leoni, E., Di Cesare, P., Riccardi, A., Bernardo, G., & Minoia, C. (2012). Serum pharmacokinetics in patients treated with transarterial chemoembolization (TACE) using two types of epirubicin-loaded microspheres. Anticancer Research, 32(5), 1769-1774.