Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Ivan Montoliu, Max Scherer, Fiona Beguelin, Laeticia DaSilva, Daniela Mari, Stefano Salvioli, François Pierre J Martin, Miriam Capri, Laura Bucci, Rita Ostan, Paolo Garagnani, Daniela Monti, Elena Biagi, Patrizia Brigidi, Martin Kussmann, Serge Rezzi, Claudio Franceschi, Sebastiano Collino

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.

Original languageEnglish
Pages (from-to)9-25
Number of pages17
JournalAging
Volume6
Issue number1
Publication statusPublished - Jan 2014

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Sphingolipids
Phospholipids
Metabolomics
Firearms
Serum
Lipids
Phenotype
Metabolome
Membrane Lipids
Antioxidants
Biomarkers
Amino Acids

Keywords

  • Biomarkers
  • Healthy aging
  • Inflammageing
  • Lipidomics
  • Metabolomics

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

Cite this

Montoliu, I., Scherer, M., Beguelin, F., DaSilva, L., Mari, D., Salvioli, S., ... Collino, S. (2014). Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity. Aging, 6(1), 9-25.

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity. / Montoliu, Ivan; Scherer, Max; Beguelin, Fiona; DaSilva, Laeticia; Mari, Daniela; Salvioli, Stefano; Martin, François Pierre J; Capri, Miriam; Bucci, Laura; Ostan, Rita; Garagnani, Paolo; Monti, Daniela; Biagi, Elena; Brigidi, Patrizia; Kussmann, Martin; Rezzi, Serge; Franceschi, Claudio; Collino, Sebastiano.

In: Aging, Vol. 6, No. 1, 01.2014, p. 9-25.

Research output: Contribution to journalArticle

Montoliu, I, Scherer, M, Beguelin, F, DaSilva, L, Mari, D, Salvioli, S, Martin, FPJ, Capri, M, Bucci, L, Ostan, R, Garagnani, P, Monti, D, Biagi, E, Brigidi, P, Kussmann, M, Rezzi, S, Franceschi, C & Collino, S 2014, 'Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity', Aging, vol. 6, no. 1, pp. 9-25.
Montoliu I, Scherer M, Beguelin F, DaSilva L, Mari D, Salvioli S et al. Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity. Aging. 2014 Jan;6(1):9-25.
Montoliu, Ivan ; Scherer, Max ; Beguelin, Fiona ; DaSilva, Laeticia ; Mari, Daniela ; Salvioli, Stefano ; Martin, François Pierre J ; Capri, Miriam ; Bucci, Laura ; Ostan, Rita ; Garagnani, Paolo ; Monti, Daniela ; Biagi, Elena ; Brigidi, Patrizia ; Kussmann, Martin ; Rezzi, Serge ; Franceschi, Claudio ; Collino, Sebastiano. / Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity. In: Aging. 2014 ; Vol. 6, No. 1. pp. 9-25.
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