Serum progesterone at human chorionic gonadotropin injection significantly correlate with female age

N. Doldi, P. Persico, L. De Santis, E. Rabellotti, F. Di Sebastiano, E. Papaleo, A. Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

Aim. In in vitro fertilization - embryo transfer (IVF-ET) higher age and low responses are associated with accelerated luteinization of mature follicles rather than diminished responsiveness. The aim of this study was to determine whether an elevated serum progesterone (P) on the day of human chorionic gonadotropin (hCG) administration during gonadotropin stimulation for IVF-ET is associated with age. Methods. E2 (17β estradiolo) and P concentrations on the day of hCG administration, number and quality of oocytes and embryos, and clinical pregnancies were retrospectively analized in 460 women undergoing IVF-ET. We evaluated patients according to age; the 25-30 age group (n=140), the 31-35 age group (n=100), the 36-40 (n=90), and the 41-45 age group (n=130). Results. In the 25-30 age group (n=140) P was 0.67±0.3 ng/mL, in the 31-35 age group (n=100) P was 0.87±0.2 ng/mL, in the 36-40 age group (n=90) P was 0.95±0.2 ng/mL, in the 41-45 age group (n=130) P was 1±0.2 ng/mL. The difference between the 25-30 age group and the 41-45 age group was statistically significant (P

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalMinerva Ginecologica
Volume57
Issue number4
Publication statusPublished - Aug 2005

Keywords

  • Age
  • In vitro fertilization
  • Premature luteinization
  • Progesterone

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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