Serum prolyl-hydroxylase as an index of fibrogenic activity in chronic active hepatitis and cirrhosist

Roberto Testa, Paolo Bindi, Domenico Risso, Stefano Borzone, Sergio Caglieris, Enrico Bardellini, Alessandro Grasso, Guido Celle

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate serum prolyl-hydroxylase, an enzyme reflecting hepatic fibrogenic activity, in healthy subjects and patients with various liver diseases. Design: Serum prolyl-hydroxylase was evaluated in patients with varying degrees of liver damage and was related to standard liver function tests. Methods: One hundred and thirty-one patients were studied, 25 with steatosis or chronic persistent hepatitis, 37 with chronic active hepatitis, 35 with Child’s class A cirrhosis and 34 with Child’s class B cirrhosis. Serum prolyl-hydroxylase was measured by means of an immune enzymatic method. Results: Serum prolyl-hydroxylase was found to be (mean ± SD) 62 ±15ng/ml in 43 healthy subjects, 70 ± 20 ng/ml in patients with steatosis or chronic persistent hepatitis, 174 ± 86 ng/ml in patients with chronic active hepatitis (P <0.01 compared with healthy and other disease groups), 124 ± 62 ng/ml (P <0.01 compared with healthy subjects) in patients with Child’s class A cirrhosis and 94 ± 55 ng/ml in those with Child’s class B cirrhosis. Serum prolyl-hydroxylase was related to liver function tests in multiple regression analysis (131 patients; r = 0.643, P <0.001) confirming the hepatic source of this enzyme in chronic liver disease. Conclusion: The higher values found in chronic active hepatitis and in the early stages of cirrhosis suggest that fibrogenesis, evaluated by means of serum prolyl-hydroxylase levels, is likely to be a reaction to inflammatory damage of the liver. On the basis of these results, serum prolyl-hydroxylase seems to be a possible marker for identifying fibrogenic activity in patients with chronic liver disease and could be a possible target for the evaluation of antifibrogenic drugs.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume5
Issue number2
Publication statusPublished - 1993

Keywords

  • Chronic active hepatitis
  • Cirrhosis
  • Fibrogenesis
  • Liver function tests
  • Prolyl-hydroxylase

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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