TY - JOUR
T1 - Serum protease inhibitors in acute viral hepatitis
AU - Meliconi, Riccardo
AU - Parracino, Oreste
AU - Facchini, Andrea
AU - Verucchi, Gabriella
AU - Chiodo, Francesco
AU - Schiattone, Maria Luisa
AU - Miglio, Federico
AU - Gasbarrini, Giovanni
PY - 1987/1
Y1 - 1987/1
N2 - Serum levels of α1-antitrypsin (α1-AT) and α2-macroglobulin (α2-M) and, as controls, α1-acid glycoprotein (α1-AG) and haptoglobin were evaluated by means of laser nephelometry in 17 patients with acute viral hepatitis (AVH) type A, 16 with AVH-B, 12 with AVH-NANB and 8 with fulminant hepatitis B. On admission, α1-AT levels were elevated in one third of AVH-A and AVH-B cases, but subsequently declined; α2-M levels were elevated in about 40% of AVH-B patients during the 2nd, 3rd and 4th week after admission. No significant correlation was found between elevated levels of protease inhibitors and aminotransferase values or drug addiction and δ coinfection. α1-acid glycoprotein and haptoglobin levels were always normal or low. Protease inhibitors did not show any elevation in fulminant hepatitis, while changes were found only in a few patients with AVH-NANB. Thus, no clearcut pattern of changes in protease inhibitors has been found in association with each type of hepatitis, although α1-AT and α2-M elevations are mainly found in AVH-B.
AB - Serum levels of α1-antitrypsin (α1-AT) and α2-macroglobulin (α2-M) and, as controls, α1-acid glycoprotein (α1-AG) and haptoglobin were evaluated by means of laser nephelometry in 17 patients with acute viral hepatitis (AVH) type A, 16 with AVH-B, 12 with AVH-NANB and 8 with fulminant hepatitis B. On admission, α1-AT levels were elevated in one third of AVH-A and AVH-B cases, but subsequently declined; α2-M levels were elevated in about 40% of AVH-B patients during the 2nd, 3rd and 4th week after admission. No significant correlation was found between elevated levels of protease inhibitors and aminotransferase values or drug addiction and δ coinfection. α1-acid glycoprotein and haptoglobin levels were always normal or low. Protease inhibitors did not show any elevation in fulminant hepatitis, while changes were found only in a few patients with AVH-NANB. Thus, no clearcut pattern of changes in protease inhibitors has been found in association with each type of hepatitis, although α1-AT and α2-M elevations are mainly found in AVH-B.
KW - α-acid glycoprotein
KW - α-antitrypsin
KW - α-macroglobulin
KW - Acute viral hepatitis
KW - Fulminant hepatitis
UR - http://www.scopus.com/inward/record.url?scp=0023077992&partnerID=8YFLogxK
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U2 - 10.1007/BF02909389
DO - 10.1007/BF02909389
M3 - Article
C2 - 2438742
AN - SCOPUS:0023077992
VL - 17
SP - 53
EP - 59
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0940-5437
IS - 1
ER -