Serum protease inhibitors in acute viral hepatitis

Riccardo Meliconi, Oreste Parracino, Andrea Facchini, Gabriella Verucchi, Francesco Chiodo, Maria Luisa Schiattone, Federico Miglio, Giovanni Gasbarrini

Research output: Contribution to journalArticlepeer-review


Serum levels of α1-antitrypsin (α1-AT) and α2-macroglobulin (α2-M) and, as controls, α1-acid glycoprotein (α1-AG) and haptoglobin were evaluated by means of laser nephelometry in 17 patients with acute viral hepatitis (AVH) type A, 16 with AVH-B, 12 with AVH-NANB and 8 with fulminant hepatitis B. On admission, α1-AT levels were elevated in one third of AVH-A and AVH-B cases, but subsequently declined; α2-M levels were elevated in about 40% of AVH-B patients during the 2nd, 3rd and 4th week after admission. No significant correlation was found between elevated levels of protease inhibitors and aminotransferase values or drug addiction and δ coinfection. α1-acid glycoprotein and haptoglobin levels were always normal or low. Protease inhibitors did not show any elevation in fulminant hepatitis, while changes were found only in a few patients with AVH-NANB. Thus, no clearcut pattern of changes in protease inhibitors has been found in association with each type of hepatitis, although α1-AT and α2-M elevations are mainly found in AVH-B.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalLa Ricerca in Clinica e in Laboratorio
Issue number1
Publication statusPublished - Jan 1987


  • α-acid glycoprotein
  • α-antitrypsin
  • α-macroglobulin
  • Acute viral hepatitis
  • Fulminant hepatitis

ASJC Scopus subject areas

  • Clinical Biochemistry


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