Abstract
1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concentration. 3 In spite of the increase in unbound fraction, both the total and free serum concentrations of phenytoin were decreased in late pregnancy. 1982 The British Pharmacological Society
Original language | English |
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Pages (from-to) | 547-552 |
Number of pages | 6 |
Journal | British Journal of Clinical Pharmacology |
Volume | 13 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1982 |
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)