Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy.

SS Chen, E. Perucca, JN Lee, A. Richens

Research output: Contribution to journalArticlepeer-review

Abstract

1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concentration. 3 In spite of the increase in unbound fraction, both the total and free serum concentrations of phenytoin were decreased in late pregnancy. 1982 The British Pharmacological Society

Original languageEnglish
Pages (from-to)547-552
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume13
Issue number4
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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