Serum protein binding of phenytoin and valproic acid in insulin-dependent diabetes mellitus

G. Gatti, F. Crema, G. Attardo-Parrinello, P. Fratino, F. Aguzzi, E. Perucca

Research output: Contribution to journalArticlepeer-review

Abstract

The serum protein binding of valproic acid (VPA) and phenytoin (PHT) was determined in spiked serum samples collected from 17 patients with insulin-dependent diabetes mellitus and 16 healthy control subjects. The free fraction of VPA was significantly greater in patients than in controls (7.6 ± 1.6% vs. 6.2 ± 1.2%, p <0.01); for PHT, free fraction values were similar in the two groups (8.2 ± 1.1% vs. 8.4 ± 1.2%). The free fraction of VPA in diabetic patients was positively correlated with free fatty acid (FFA) concentration (r = 0.79, p <0.01). No significant relationships could be found between free drug fraction and either serum albumin or glycosylated protein concentration.

Original languageEnglish
Pages (from-to)389-391
Number of pages3
JournalTherapeutic Drug Monitoring
Volume9
Issue number4
Publication statusPublished - 1987

Keywords

  • Diabetes mellitus
  • Free drug
  • Phenytoin
  • Protein binding
  • Valproic acid

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Toxicology

Fingerprint

Dive into the research topics of 'Serum protein binding of phenytoin and valproic acid in insulin-dependent diabetes mellitus'. Together they form a unique fingerprint.

Cite this