Serum protein pattern during cow pregnancy

Acute-phase proteins increase in the peripartum period

Fausto Cairoli, Massimiliano Battocchio, Maria Cristina Veronesi, Daniela Brambilla, Francesca Conserva, Ivano Eberini, Robin Wait, Elisabetta Gianazza

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Serum collected in a time-course mode during the pregnancy of a group of heifers was analyzed by 2-DE under various experimental conditions to optimize resolution of all protein spots. Changes in the levels of some components were detected during the last phase of pregnancy and early postpartum. These included a decrease of α 2-HS-glycoprotein, an increase of α 1-antichymotrypsin and, with a much larger and more abrupt variation, of orosomucoid and haptoglobin. These findings associate the weeks preceding calving with an acute-phase reaction. Analysis of individual animal's sera by 1-DE demonstrated a higher level of orosomucoid in the sera of cows developing postpartum endometritis during the 2 wk after calving (i.e., in the course of the infection) but a lower level during the 2 wk before calving. This observation could represent an important tool for the prepartum detection of animals prone to develop postpartum endometritis and lead to a more accurate peripartum management of those animals.

Original languageEnglish
Pages (from-to)1617-1625
Number of pages9
JournalElectrophoresis
Volume27
Issue number8
DOIs
Publication statusPublished - Apr 2006

Fingerprint

Peripartum Period
Acute-Phase Proteins
Postpartum Period
Orosomucoid
Endometritis
Blood Proteins
Animals
Pregnancy
Serum
Acute-Phase Reaction
Haptoglobins
Glycoproteins
Infection
Proteins

Keywords

  • Endometritis
  • Haptoglobin
  • Orosomucoid
  • Peripartum
  • Pregnancy

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Cairoli, F., Battocchio, M., Veronesi, M. C., Brambilla, D., Conserva, F., Eberini, I., ... Gianazza, E. (2006). Serum protein pattern during cow pregnancy: Acute-phase proteins increase in the peripartum period. Electrophoresis, 27(8), 1617-1625. https://doi.org/10.1002/elps.200500742

Serum protein pattern during cow pregnancy : Acute-phase proteins increase in the peripartum period. / Cairoli, Fausto; Battocchio, Massimiliano; Veronesi, Maria Cristina; Brambilla, Daniela; Conserva, Francesca; Eberini, Ivano; Wait, Robin; Gianazza, Elisabetta.

In: Electrophoresis, Vol. 27, No. 8, 04.2006, p. 1617-1625.

Research output: Contribution to journalArticle

Cairoli, F, Battocchio, M, Veronesi, MC, Brambilla, D, Conserva, F, Eberini, I, Wait, R & Gianazza, E 2006, 'Serum protein pattern during cow pregnancy: Acute-phase proteins increase in the peripartum period', Electrophoresis, vol. 27, no. 8, pp. 1617-1625. https://doi.org/10.1002/elps.200500742
Cairoli, Fausto ; Battocchio, Massimiliano ; Veronesi, Maria Cristina ; Brambilla, Daniela ; Conserva, Francesca ; Eberini, Ivano ; Wait, Robin ; Gianazza, Elisabetta. / Serum protein pattern during cow pregnancy : Acute-phase proteins increase in the peripartum period. In: Electrophoresis. 2006 ; Vol. 27, No. 8. pp. 1617-1625.
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