Serum protein pattern during cow pregnancy: Acute-phase proteins increase in the peripartum period

Fausto Cairoli, Massimiliano Battocchio, Maria Cristina Veronesi, Daniela Brambilla, Francesca Conserva, Ivano Eberini, Robin Wait, Elisabetta Gianazza

Research output: Contribution to journalArticlepeer-review


Serum collected in a time-course mode during the pregnancy of a group of heifers was analyzed by 2-DE under various experimental conditions to optimize resolution of all protein spots. Changes in the levels of some components were detected during the last phase of pregnancy and early postpartum. These included a decrease of α 2-HS-glycoprotein, an increase of α 1-antichymotrypsin and, with a much larger and more abrupt variation, of orosomucoid and haptoglobin. These findings associate the weeks preceding calving with an acute-phase reaction. Analysis of individual animal's sera by 1-DE demonstrated a higher level of orosomucoid in the sera of cows developing postpartum endometritis during the 2 wk after calving (i.e., in the course of the infection) but a lower level during the 2 wk before calving. This observation could represent an important tool for the prepartum detection of animals prone to develop postpartum endometritis and lead to a more accurate peripartum management of those animals.

Original languageEnglish
Pages (from-to)1617-1625
Number of pages9
Issue number8
Publication statusPublished - Apr 2006


  • Endometritis
  • Haptoglobin
  • Orosomucoid
  • Peripartum
  • Pregnancy

ASJC Scopus subject areas

  • Clinical Biochemistry


Dive into the research topics of 'Serum protein pattern during cow pregnancy: Acute-phase proteins increase in the peripartum period'. Together they form a unique fingerprint.

Cite this