Serum resistin and glomerular filtration rate in patients with type 2 diabetes

Lorena Ortega Moreno, Lucia Salvemini, Christine Mendonca, Massimiliano Copetti, Concetta De Bonis, Salvatore De Cosmo, Alessandro Doria, Vincenzo Trischitta, Claudia Menzaghi

Research output: Contribution to journalArticle

Abstract

Background: High serum levels of the pro-inflammatory adipokine resistin have been associated with decreased renal function in the general population. The goal of this study was to investigate whether such association is also present among diabetic subjects, who are at increased risk of renal function loss. Methods: The cross-sectional association between serum resistin levels and estimated glomerular filtration rate (eGFR) was investigated in 1,560 type 2 diabetic (T2D) patients of European ancestry comprised in two different cohorts: 762 patients from San Giovanni Rotondo (SGR; Italy) and 798 patients from Boston (US). Results: Serum resistin was inversely associated with eGFR in SGR [β (SE) for one SD of resistin increment = -1.01 (0.70) ml/min/1.73m2, p = 0.019] and in Boston [β (SE) = -5.31 (0.74) ml/min/1.73m2, p <0.001] samples, as well as in the two studies combined [β (SE) = -3.42 (0.52) ml/min/1.73m2, p <0.001]. The association was unaffected by adjustment for smoking habits, BMI, waist circumference, diabetes duration, HbA1c, insulin treatment, hypertension and lipid-lowering therapy: β (SE) for one SD of resistin increment = -1.07 (0.70), p = 0.02; -5.50 (0.88), p <0.001; and -2.81 (0.55) ml/min/1.73m2, p <.001, in SGR, Boston and the two studies combined, respectively. The association was significantly stronger in men than in women (p for resistin-by-gender interaction = 0.003). For each resistin SD increment, the odds of having eGFR <0 ml/min/1.73m2 increased by 22% (OR = 1.22; 95% CI 1.02-1.44; p = 0.025) in SGR sample, 69% (OR = 1.69; 95% CI 1.38-2.07; p <0.001) in Boston sample, and 47% (OR = 1.47; 95% CI 1.29-1.68; p <0.001) in the two studies considered together. Similar associations were observed in the adjusted model: OR 95% CI for each SD resistin increment being 1.23 (1.03-1.46), p = 0.021; 1.52 (1.20-1.92), p <0.001; 1.33 (1.16-1.53), p <0.001, in SGR, Boston and the two studies combined, respectively. Conclusions: This is the first report of an association between high serum resistin and low eGFR in patients with T2D of European ancestry.

Original languageEnglish
Article numbere0119529
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 26 2015

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resistin
Resistin
glomerular filtration rate
Medical problems
Glomerular Filtration Rate
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Serum
renal function
ancestry
Kidney
adipokines
glycohemoglobin
Adipokines
smoking (habit)
waist circumference
Waist Circumference
sampling
Italy
hypertension

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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Serum resistin and glomerular filtration rate in patients with type 2 diabetes. / Moreno, Lorena Ortega; Salvemini, Lucia; Mendonca, Christine; Copetti, Massimiliano; De Bonis, Concetta; De Cosmo, Salvatore; Doria, Alessandro; Trischitta, Vincenzo; Menzaghi, Claudia.

In: PLoS One, Vol. 10, No. 3, e0119529, 26.03.2015.

Research output: Contribution to journalArticle

Moreno, Lorena Ortega ; Salvemini, Lucia ; Mendonca, Christine ; Copetti, Massimiliano ; De Bonis, Concetta ; De Cosmo, Salvatore ; Doria, Alessandro ; Trischitta, Vincenzo ; Menzaghi, Claudia. / Serum resistin and glomerular filtration rate in patients with type 2 diabetes. In: PLoS One. 2015 ; Vol. 10, No. 3.
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title = "Serum resistin and glomerular filtration rate in patients with type 2 diabetes",
abstract = "Background: High serum levels of the pro-inflammatory adipokine resistin have been associated with decreased renal function in the general population. The goal of this study was to investigate whether such association is also present among diabetic subjects, who are at increased risk of renal function loss. Methods: The cross-sectional association between serum resistin levels and estimated glomerular filtration rate (eGFR) was investigated in 1,560 type 2 diabetic (T2D) patients of European ancestry comprised in two different cohorts: 762 patients from San Giovanni Rotondo (SGR; Italy) and 798 patients from Boston (US). Results: Serum resistin was inversely associated with eGFR in SGR [β (SE) for one SD of resistin increment = -1.01 (0.70) ml/min/1.73m2, p = 0.019] and in Boston [β (SE) = -5.31 (0.74) ml/min/1.73m2, p <0.001] samples, as well as in the two studies combined [β (SE) = -3.42 (0.52) ml/min/1.73m2, p <0.001]. The association was unaffected by adjustment for smoking habits, BMI, waist circumference, diabetes duration, HbA1c, insulin treatment, hypertension and lipid-lowering therapy: β (SE) for one SD of resistin increment = -1.07 (0.70), p = 0.02; -5.50 (0.88), p <0.001; and -2.81 (0.55) ml/min/1.73m2, p <.001, in SGR, Boston and the two studies combined, respectively. The association was significantly stronger in men than in women (p for resistin-by-gender interaction = 0.003). For each resistin SD increment, the odds of having eGFR <0 ml/min/1.73m2 increased by 22{\%} (OR = 1.22; 95{\%} CI 1.02-1.44; p = 0.025) in SGR sample, 69{\%} (OR = 1.69; 95{\%} CI 1.38-2.07; p <0.001) in Boston sample, and 47{\%} (OR = 1.47; 95{\%} CI 1.29-1.68; p <0.001) in the two studies considered together. Similar associations were observed in the adjusted model: OR 95{\%} CI for each SD resistin increment being 1.23 (1.03-1.46), p = 0.021; 1.52 (1.20-1.92), p <0.001; 1.33 (1.16-1.53), p <0.001, in SGR, Boston and the two studies combined, respectively. Conclusions: This is the first report of an association between high serum resistin and low eGFR in patients with T2D of European ancestry.",
author = "Moreno, {Lorena Ortega} and Lucia Salvemini and Christine Mendonca and Massimiliano Copetti and {De Bonis}, Concetta and {De Cosmo}, Salvatore and Alessandro Doria and Vincenzo Trischitta and Claudia Menzaghi",
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T1 - Serum resistin and glomerular filtration rate in patients with type 2 diabetes

AU - Moreno, Lorena Ortega

AU - Salvemini, Lucia

AU - Mendonca, Christine

AU - Copetti, Massimiliano

AU - De Bonis, Concetta

AU - De Cosmo, Salvatore

AU - Doria, Alessandro

AU - Trischitta, Vincenzo

AU - Menzaghi, Claudia

PY - 2015/3/26

Y1 - 2015/3/26

N2 - Background: High serum levels of the pro-inflammatory adipokine resistin have been associated with decreased renal function in the general population. The goal of this study was to investigate whether such association is also present among diabetic subjects, who are at increased risk of renal function loss. Methods: The cross-sectional association between serum resistin levels and estimated glomerular filtration rate (eGFR) was investigated in 1,560 type 2 diabetic (T2D) patients of European ancestry comprised in two different cohorts: 762 patients from San Giovanni Rotondo (SGR; Italy) and 798 patients from Boston (US). Results: Serum resistin was inversely associated with eGFR in SGR [β (SE) for one SD of resistin increment = -1.01 (0.70) ml/min/1.73m2, p = 0.019] and in Boston [β (SE) = -5.31 (0.74) ml/min/1.73m2, p <0.001] samples, as well as in the two studies combined [β (SE) = -3.42 (0.52) ml/min/1.73m2, p <0.001]. The association was unaffected by adjustment for smoking habits, BMI, waist circumference, diabetes duration, HbA1c, insulin treatment, hypertension and lipid-lowering therapy: β (SE) for one SD of resistin increment = -1.07 (0.70), p = 0.02; -5.50 (0.88), p <0.001; and -2.81 (0.55) ml/min/1.73m2, p <.001, in SGR, Boston and the two studies combined, respectively. The association was significantly stronger in men than in women (p for resistin-by-gender interaction = 0.003). For each resistin SD increment, the odds of having eGFR <0 ml/min/1.73m2 increased by 22% (OR = 1.22; 95% CI 1.02-1.44; p = 0.025) in SGR sample, 69% (OR = 1.69; 95% CI 1.38-2.07; p <0.001) in Boston sample, and 47% (OR = 1.47; 95% CI 1.29-1.68; p <0.001) in the two studies considered together. Similar associations were observed in the adjusted model: OR 95% CI for each SD resistin increment being 1.23 (1.03-1.46), p = 0.021; 1.52 (1.20-1.92), p <0.001; 1.33 (1.16-1.53), p <0.001, in SGR, Boston and the two studies combined, respectively. Conclusions: This is the first report of an association between high serum resistin and low eGFR in patients with T2D of European ancestry.

AB - Background: High serum levels of the pro-inflammatory adipokine resistin have been associated with decreased renal function in the general population. The goal of this study was to investigate whether such association is also present among diabetic subjects, who are at increased risk of renal function loss. Methods: The cross-sectional association between serum resistin levels and estimated glomerular filtration rate (eGFR) was investigated in 1,560 type 2 diabetic (T2D) patients of European ancestry comprised in two different cohorts: 762 patients from San Giovanni Rotondo (SGR; Italy) and 798 patients from Boston (US). Results: Serum resistin was inversely associated with eGFR in SGR [β (SE) for one SD of resistin increment = -1.01 (0.70) ml/min/1.73m2, p = 0.019] and in Boston [β (SE) = -5.31 (0.74) ml/min/1.73m2, p <0.001] samples, as well as in the two studies combined [β (SE) = -3.42 (0.52) ml/min/1.73m2, p <0.001]. The association was unaffected by adjustment for smoking habits, BMI, waist circumference, diabetes duration, HbA1c, insulin treatment, hypertension and lipid-lowering therapy: β (SE) for one SD of resistin increment = -1.07 (0.70), p = 0.02; -5.50 (0.88), p <0.001; and -2.81 (0.55) ml/min/1.73m2, p <.001, in SGR, Boston and the two studies combined, respectively. The association was significantly stronger in men than in women (p for resistin-by-gender interaction = 0.003). For each resistin SD increment, the odds of having eGFR <0 ml/min/1.73m2 increased by 22% (OR = 1.22; 95% CI 1.02-1.44; p = 0.025) in SGR sample, 69% (OR = 1.69; 95% CI 1.38-2.07; p <0.001) in Boston sample, and 47% (OR = 1.47; 95% CI 1.29-1.68; p <0.001) in the two studies considered together. Similar associations were observed in the adjusted model: OR 95% CI for each SD resistin increment being 1.23 (1.03-1.46), p = 0.021; 1.52 (1.20-1.92), p <0.001; 1.33 (1.16-1.53), p <0.001, in SGR, Boston and the two studies combined, respectively. Conclusions: This is the first report of an association between high serum resistin and low eGFR in patients with T2D of European ancestry.

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