Serum-soluble E-cadherin fragments in lung cancer

Michele Cioffi, Patrizia Gazzerro, Bruno Di Finizio, Maria Teresa Vietri, Catia Di Macchia, Giovanni Alfredo Puca, Anna Maria Molinari

Research output: Contribution to journalArticlepeer-review

Abstract

Aims and background: E-cadherin, also known as uvomorulin or cell-CAM 120/80, is one of the subclasses of cadherins, CA 2+-dependent cell adhesion molecules. Several recent studies have suggested that loss of E-cadherin may be associated with tumor progression, such as in lung, gastric, hepatocellular, breast and prostatic carcinoma. Assessment of E-cadherin serum levels in lung cancer showed a relation to histologic type. Methods and study design: Using an enzyme immunoassay, we determined E-cadherin serum levels in 79 patients affected with lung cancer (stage I-IV), 9 patients with breast cancer, 23 patients with different benign diseases, and 20 healthy patients. Results: At a specificity level of 90%, E-cadherin diagnostic sensitivity was 66.6%, 47.6% and 43.7% in patients affected with squamous cell carcinoma, small cell carcinoma and adenocarcinoma, respectively. Conclusions: Preliminary results suggest the use of serum E-cadherin as a prospective tumor marker.

Original languageEnglish
Pages (from-to)32-34
Number of pages3
JournalTumori
Volume85
Issue number1
Publication statusPublished - Jan 1999

Keywords

  • E-cadherin
  • IEMA method
  • Lung cancer
  • Tumor marker

ASJC Scopus subject areas

  • Cancer Research

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