TY - JOUR
T1 - Serum-soluble E-cadherin fragments in lung cancer
AU - Cioffi, Michele
AU - Gazzerro, Patrizia
AU - Di Finizio, Bruno
AU - Vietri, Maria Teresa
AU - Di Macchia, Catia
AU - Puca, Giovanni Alfredo
AU - Molinari, Anna Maria
PY - 1999/1
Y1 - 1999/1
N2 - Aims and background: E-cadherin, also known as uvomorulin or cell-CAM 120/80, is one of the subclasses of cadherins, CA
2+-dependent cell adhesion molecules. Several recent studies have suggested that loss of E-cadherin may be associated with tumor progression, such as in lung, gastric, hepatocellular, breast and prostatic carcinoma. Assessment of E-cadherin serum levels in lung cancer showed a relation to histologic type. Methods and study design: Using an enzyme immunoassay, we determined E-cadherin serum levels in 79 patients affected with lung cancer (stage I-IV), 9 patients with breast cancer, 23 patients with different benign diseases, and 20 healthy patients. Results: At a specificity level of 90%, E-cadherin diagnostic sensitivity was 66.6%, 47.6% and 43.7% in patients affected with squamous cell carcinoma, small cell carcinoma and adenocarcinoma, respectively. Conclusions: Preliminary results suggest the use of serum E-cadherin as a prospective tumor marker.
AB - Aims and background: E-cadherin, also known as uvomorulin or cell-CAM 120/80, is one of the subclasses of cadherins, CA
2+-dependent cell adhesion molecules. Several recent studies have suggested that loss of E-cadherin may be associated with tumor progression, such as in lung, gastric, hepatocellular, breast and prostatic carcinoma. Assessment of E-cadherin serum levels in lung cancer showed a relation to histologic type. Methods and study design: Using an enzyme immunoassay, we determined E-cadherin serum levels in 79 patients affected with lung cancer (stage I-IV), 9 patients with breast cancer, 23 patients with different benign diseases, and 20 healthy patients. Results: At a specificity level of 90%, E-cadherin diagnostic sensitivity was 66.6%, 47.6% and 43.7% in patients affected with squamous cell carcinoma, small cell carcinoma and adenocarcinoma, respectively. Conclusions: Preliminary results suggest the use of serum E-cadherin as a prospective tumor marker.
KW - E-cadherin
KW - IEMA method
KW - Lung cancer
KW - Tumor marker
UR - http://www.scopus.com/inward/record.url?scp=0033045449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033045449&partnerID=8YFLogxK
M3 - Article
C2 - 10228494
AN - SCOPUS:0033045449
VL - 85
SP - 32
EP - 34
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 1
ER -