Serum testosterone predicts cardiorespiratory fitness impairment in normal-weight women with polycystic ovary syndrome

Elisabetta Bacchi, Carlo Negri, Daniela Di Sarra, Flavia Tosi, Cantor Tarperi, Rossella Moretta, Federico Schena, Enzo Bonora, Jean Marc Kaufman, Paolo Moghetti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Limited literature has shown that maximal oxygen consumption (V'O2max), that is the maximal capacity of an individual to perform aerobic work, may be lowered in overweight/obese women with polycystic ovary syndrome (PCOS). However, it remains unclear whether this impairment is associated with PCOS per se or is entirely due to body fat excess. Our objective was to assess whether cardiorespiratory fitness is altered in normal-weight PCOS women and to investigate which factors are associated with this phenomenon. Subjects: Fifteen normal-weight PCOS women and 15 age- and BMI-matched healthy controls. Fourteen subjects in each group completed the protocol. Measurements: V'O2max and ventilatory thresholds (maximal incremental cycle ergometer test with breath-by-breath analysis of gas exchange), insulin sensitivity (hyperinsulinaemic euglycaemic clamp) and androgenaemia (serum total and free testosterone, measured by liquid chromatography mass spectrometry and equilibrium dialysis) were accurately assessed. Results: Maximal V'O2 and power were strikingly impaired in normal-weight PCOS individuals, as compared with healthy controls (29·4 ± 1·5 vs 35·8 ± 1·6 ml O2/kg/min, P = 0·008; 138 ± 6 vs 170 ± 10 W, P = 0·011, respectively). Similarly, oxygen consumption and power at both the first and second ventilatory thresholds were significantly lower in PCOS subjects than in healthy women. In multiple regression analysis, V'O2max was negatively predicted by serum-free testosterone levels, but not by body fat mass and glucose disposal rate (R2 = 0·45 P = 0·013). Conclusions: Cardiorespiratory fitness is impaired in normal-weight PCOS women. Androgen excess but not insulin sensitivity is associated with this alteration.

Original languageEnglish
JournalClinical Endocrinology
DOIs
Publication statusAccepted/In press - 2015

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Polycystic Ovary Syndrome
Testosterone
Weights and Measures
Serum
Oxygen Consumption
Insulin Resistance
Adipose Tissue
Breath Tests
Glucose Clamp Technique
Cardiorespiratory Fitness
Liquid Chromatography
Androgens
Dialysis
Mass Spectrometry
Healthy Volunteers
Gases
Regression Analysis
Glucose

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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Serum testosterone predicts cardiorespiratory fitness impairment in normal-weight women with polycystic ovary syndrome. / Bacchi, Elisabetta; Negri, Carlo; Di Sarra, Daniela; Tosi, Flavia; Tarperi, Cantor; Moretta, Rossella; Schena, Federico; Bonora, Enzo; Kaufman, Jean Marc; Moghetti, Paolo.

In: Clinical Endocrinology, 2015.

Research output: Contribution to journalArticle

Bacchi, Elisabetta ; Negri, Carlo ; Di Sarra, Daniela ; Tosi, Flavia ; Tarperi, Cantor ; Moretta, Rossella ; Schena, Federico ; Bonora, Enzo ; Kaufman, Jean Marc ; Moghetti, Paolo. / Serum testosterone predicts cardiorespiratory fitness impairment in normal-weight women with polycystic ovary syndrome. In: Clinical Endocrinology. 2015.
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abstract = "Objective: Limited literature has shown that maximal oxygen consumption (V'O2max), that is the maximal capacity of an individual to perform aerobic work, may be lowered in overweight/obese women with polycystic ovary syndrome (PCOS). However, it remains unclear whether this impairment is associated with PCOS per se or is entirely due to body fat excess. Our objective was to assess whether cardiorespiratory fitness is altered in normal-weight PCOS women and to investigate which factors are associated with this phenomenon. Subjects: Fifteen normal-weight PCOS women and 15 age- and BMI-matched healthy controls. Fourteen subjects in each group completed the protocol. Measurements: V'O2max and ventilatory thresholds (maximal incremental cycle ergometer test with breath-by-breath analysis of gas exchange), insulin sensitivity (hyperinsulinaemic euglycaemic clamp) and androgenaemia (serum total and free testosterone, measured by liquid chromatography mass spectrometry and equilibrium dialysis) were accurately assessed. Results: Maximal V'O2 and power were strikingly impaired in normal-weight PCOS individuals, as compared with healthy controls (29·4 ± 1·5 vs 35·8 ± 1·6 ml O2/kg/min, P = 0·008; 138 ± 6 vs 170 ± 10 W, P = 0·011, respectively). Similarly, oxygen consumption and power at both the first and second ventilatory thresholds were significantly lower in PCOS subjects than in healthy women. In multiple regression analysis, V'O2max was negatively predicted by serum-free testosterone levels, but not by body fat mass and glucose disposal rate (R2 = 0·45 P = 0·013). Conclusions: Cardiorespiratory fitness is impaired in normal-weight PCOS women. Androgen excess but not insulin sensitivity is associated with this alteration.",
author = "Elisabetta Bacchi and Carlo Negri and {Di Sarra}, Daniela and Flavia Tosi and Cantor Tarperi and Rossella Moretta and Federico Schena and Enzo Bonora and Kaufman, {Jean Marc} and Paolo Moghetti",
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AU - Bacchi, Elisabetta

AU - Negri, Carlo

AU - Di Sarra, Daniela

AU - Tosi, Flavia

AU - Tarperi, Cantor

AU - Moretta, Rossella

AU - Schena, Federico

AU - Bonora, Enzo

AU - Kaufman, Jean Marc

AU - Moghetti, Paolo

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N2 - Objective: Limited literature has shown that maximal oxygen consumption (V'O2max), that is the maximal capacity of an individual to perform aerobic work, may be lowered in overweight/obese women with polycystic ovary syndrome (PCOS). However, it remains unclear whether this impairment is associated with PCOS per se or is entirely due to body fat excess. Our objective was to assess whether cardiorespiratory fitness is altered in normal-weight PCOS women and to investigate which factors are associated with this phenomenon. Subjects: Fifteen normal-weight PCOS women and 15 age- and BMI-matched healthy controls. Fourteen subjects in each group completed the protocol. Measurements: V'O2max and ventilatory thresholds (maximal incremental cycle ergometer test with breath-by-breath analysis of gas exchange), insulin sensitivity (hyperinsulinaemic euglycaemic clamp) and androgenaemia (serum total and free testosterone, measured by liquid chromatography mass spectrometry and equilibrium dialysis) were accurately assessed. Results: Maximal V'O2 and power were strikingly impaired in normal-weight PCOS individuals, as compared with healthy controls (29·4 ± 1·5 vs 35·8 ± 1·6 ml O2/kg/min, P = 0·008; 138 ± 6 vs 170 ± 10 W, P = 0·011, respectively). Similarly, oxygen consumption and power at both the first and second ventilatory thresholds were significantly lower in PCOS subjects than in healthy women. In multiple regression analysis, V'O2max was negatively predicted by serum-free testosterone levels, but not by body fat mass and glucose disposal rate (R2 = 0·45 P = 0·013). Conclusions: Cardiorespiratory fitness is impaired in normal-weight PCOS women. Androgen excess but not insulin sensitivity is associated with this alteration.

AB - Objective: Limited literature has shown that maximal oxygen consumption (V'O2max), that is the maximal capacity of an individual to perform aerobic work, may be lowered in overweight/obese women with polycystic ovary syndrome (PCOS). However, it remains unclear whether this impairment is associated with PCOS per se or is entirely due to body fat excess. Our objective was to assess whether cardiorespiratory fitness is altered in normal-weight PCOS women and to investigate which factors are associated with this phenomenon. Subjects: Fifteen normal-weight PCOS women and 15 age- and BMI-matched healthy controls. Fourteen subjects in each group completed the protocol. Measurements: V'O2max and ventilatory thresholds (maximal incremental cycle ergometer test with breath-by-breath analysis of gas exchange), insulin sensitivity (hyperinsulinaemic euglycaemic clamp) and androgenaemia (serum total and free testosterone, measured by liquid chromatography mass spectrometry and equilibrium dialysis) were accurately assessed. Results: Maximal V'O2 and power were strikingly impaired in normal-weight PCOS individuals, as compared with healthy controls (29·4 ± 1·5 vs 35·8 ± 1·6 ml O2/kg/min, P = 0·008; 138 ± 6 vs 170 ± 10 W, P = 0·011, respectively). Similarly, oxygen consumption and power at both the first and second ventilatory thresholds were significantly lower in PCOS subjects than in healthy women. In multiple regression analysis, V'O2max was negatively predicted by serum-free testosterone levels, but not by body fat mass and glucose disposal rate (R2 = 0·45 P = 0·013). Conclusions: Cardiorespiratory fitness is impaired in normal-weight PCOS women. Androgen excess but not insulin sensitivity is associated with this alteration.

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