Serum thymidine activity and somatomedin-c levels in children and adolescents with turner’s syndrome: Effect of chronic estrogen and progestogen replacement therapy

Sylvie Guidoux, Mauro Bozzola, Daniela Larizza, Rose Marie Schimpff

Research output: Contribution to journalArticle


Turner’s syndrome has been used as a model of primary hypogonadism to assess the role of estrogen-progestogen replacement therapy on scrum thymidine activity (TA) and somatomcdin-C (Sm-C) levels. 33 subjects with gonadal dysgenesis were studied: 10 untreated and 13 treated with estrogen-progestogen combination. In 10 untreated patients serum TA was 1.02 ± (SEM) 0.04 U/ml and serum Sm-C value was 27.82 ±4.14 nmol/1. both similar to those in the age-matched normal children. A positive correlation was found between Sm-C and the bone age (r = 0.891. ρ <0.002). In the i3 treated subjects, the estrogen-progestogen combination as replacement therapy induced a significant increase in Sm-C level (40.52 ± 4.30 nmol/1, ρ <0.05). No variation was observed for serum thymidine activity between the two groups of subjects.

Original languageEnglish
Pages (from-to)256-262
Number of pages7
JournalHormone Research in Paediatrics
Issue number4
Publication statusPublished - 1986



  • Estrogen replacement therapy
  • Sm-C
  • Thymidine activity
  • Tumor’s syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

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