TY - JOUR
T1 - Serum thyrotropin concentration in children with isolated thyroid nodules
AU - Mussa, Alessandro
AU - Salerno, Maria Carolina
AU - Bona, Gianni
AU - Wasniewska, Malgorzata
AU - Segni, Maria
AU - Cassio, Alessandra
AU - Vigone, Maria Cristina
AU - Gastaldi, Roberto
AU - Iughetti, Lorenzo
AU - Santanera, Arianna
AU - Capalbo, Donatella
AU - Matarazzo, Patrizia
AU - De Luca, Filippo
AU - Weber, Giovanna
AU - Corrias, Andrea
PY - 2013/11
Y1 - 2013/11
N2 - Objective To investigate the correlation between serum thyroid-stimulating hormone (TSH) concentration and nodule nature in pediatric patients with thyroid nodules, with the aim of identifying a marker able to differentiate benign and malignant nodules. Study design This was a retrospective analysis of serum TSH concentrations in a multicentric case series of 125 pediatric patients with benign and malignant thyroid nodules. Results Of the 125 patients, 99 had benign thyroid nodules and 26 had differentiated thyroid cancer (24 papillary and 2 follicular). Final diagnosis was based on surgery in 57 cases and on a benign cytology plus clinical follow-up in 68 cases. Serum TSH concentration was significantly higher in patients with thyroid cancer compared with those with benign nodules (3.23 ± 1.59 mU/L vs 1.64 ± 0.99 mU/L; P 2.8 mU/L), serum TSH concentration can serve as a predictor of thyroid cancer in pediatric patients with thyroid nodules and can inform the decision of when to submit patients to further investigation by cytology.
AB - Objective To investigate the correlation between serum thyroid-stimulating hormone (TSH) concentration and nodule nature in pediatric patients with thyroid nodules, with the aim of identifying a marker able to differentiate benign and malignant nodules. Study design This was a retrospective analysis of serum TSH concentrations in a multicentric case series of 125 pediatric patients with benign and malignant thyroid nodules. Results Of the 125 patients, 99 had benign thyroid nodules and 26 had differentiated thyroid cancer (24 papillary and 2 follicular). Final diagnosis was based on surgery in 57 cases and on a benign cytology plus clinical follow-up in 68 cases. Serum TSH concentration was significantly higher in patients with thyroid cancer compared with those with benign nodules (3.23 ± 1.59 mU/L vs 1.64 ± 0.99 mU/L; P 2.8 mU/L), serum TSH concentration can serve as a predictor of thyroid cancer in pediatric patients with thyroid nodules and can inform the decision of when to submit patients to further investigation by cytology.
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U2 - 10.1016/j.jpeds.2013.07.003
DO - 10.1016/j.jpeds.2013.07.003
M3 - Article
C2 - 23972643
AN - SCOPUS:84886722211
VL - 163
SP - 1465
EP - 1470
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 5
ER -