Serum thyrotropin concentration in children with isolated thyroid nodules

Alessandro Mussa, Maria Carolina Salerno, Gianni Bona, Malgorzata Wasniewska, Maria Segni, Alessandra Cassio, Maria Cristina Vigone, Roberto Gastaldi, Lorenzo Iughetti, Arianna Santanera, Donatella Capalbo, Patrizia Matarazzo, Filippo De Luca, Giovanna Weber, Andrea Corrias

Research output: Contribution to journalArticlepeer-review


Objective To investigate the correlation between serum thyroid-stimulating hormone (TSH) concentration and nodule nature in pediatric patients with thyroid nodules, with the aim of identifying a marker able to differentiate benign and malignant nodules. Study design This was a retrospective analysis of serum TSH concentrations in a multicentric case series of 125 pediatric patients with benign and malignant thyroid nodules. Results Of the 125 patients, 99 had benign thyroid nodules and 26 had differentiated thyroid cancer (24 papillary and 2 follicular). Final diagnosis was based on surgery in 57 cases and on a benign cytology plus clinical follow-up in 68 cases. Serum TSH concentration was significantly higher in patients with thyroid cancer compared with those with benign nodules (3.23 ± 1.59 mU/L vs 1.64 ± 0.99 mU/L; P 2.8 mU/L), serum TSH concentration can serve as a predictor of thyroid cancer in pediatric patients with thyroid nodules and can inform the decision of when to submit patients to further investigation by cytology.

Original languageEnglish
Pages (from-to)1465-1470
Number of pages6
JournalJournal of Pediatrics
Issue number5
Publication statusPublished - Nov 2013

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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