Serum TNF-alpha levels correlate with disease severity and are reduced by effective therapy in plaque-type psoriasis

A. Mussi, C. Bonifati, M. Carducci, G. D'Agosto, F. Pimpinelli, D. D'Urso, L. D'Auria, M. Fazio, F. Ameglio

Research output: Contribution to journalArticle

Abstract

TNF-alpha is a pleiotropic cytokine possibly involved in the pathogenesis of psoriasis. Objective: to analyze the serum TNF-alpha levels in plaque-type psoriatic patients to evaluate the concentrations, correlation with the severity score and behaviour after therapy. The serum TNF-alpha levels of thirty-seven patients (25 females and 12 males; median age: 52.5 years, range 18-81: median PASI score: 11.4, range 3.5-42) and thirty healthy controls (21 females and 9 males, median age: 48,5 years, range 25-77) were compared after measurements obtained employing commercially available ELISA kits. The median serum TNF-alpha levels of the patients were significantly higher than those of controls (p = 0.004). 30/37 patients were followed over time at 2 and 4 weeks of treatment. Twenty one subjects were also observed after 6 weeks. After effective treatments, both the PASI scores and the cytokine levels were significantly and concomitantly reduced (p <0.001). Significant correlations were found when the TNF-alpha values were plotted against the PASI scores both at the time of patient enrollment and at all the subsequent times (118 observations). A significant correlation was observed between circulating TNF-alpha and sE-selectin in agreement with a possible functional activity of the cytokine. However, no correlation was found between the cytokine levels and other 4 soluble membrane molecules. Our findings indicate that the molecule studied, although non specific for the disease considered, presents a behaviour paralleling that of the disease severity and therefore might have clinical usefulness, particularly in monitoring the therapeutic effects.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalJournal of Biological Regulators and Homeostatic Agents
Volume11
Issue number3
Publication statusPublished - Jul 1997

Keywords

  • PASI score
  • Psoriasis
  • sE-selectin
  • Serum
  • TNF-alpha

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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