TY - JOUR
T1 - Serum total lipids, lipoprotein cholesterol, and apolipoprotein A in acute viral hepatitis and chronic liver disease
AU - Vergani, C.
AU - Trovato, G.
AU - Delu, A.
AU - Pietrogrande, M.
AU - Dioguardi, N.
PY - 1978
Y1 - 1978
N2 - Serum total lipids, lipoprotein cholesterol, apolipoprotein A (Apo A), and liver function tests have been investigated in patients with acute viral hepatitis and chronic liver disease. Hypertriglyceridaemia, absence of α and pre β bands on the lipoprotein electrophoresis pattern, low level of Apo A, and presence of abnormal lipoproteins (β-VLDL and β2-LP) were observed in the early phase of acute hepatitis. A positive correlation was found between Apo A and high-density lipoprotein cholesterol, and a negative one between Apo A and triglyceride, bile acids, total bilirubin, and serum alanine aminotransferase. Lipoprotein abnormalities in the early phase of acute hepatitis are probably due to low lecithin-cholesterol acyltransferase activity. The reappearance of α lipoprotein and the increase of Apo A are sensitive indices of improvement of liver function. In chronic liver disease low levels of cholesterol and Apo A indicate the severity of liver cell injury.
AB - Serum total lipids, lipoprotein cholesterol, apolipoprotein A (Apo A), and liver function tests have been investigated in patients with acute viral hepatitis and chronic liver disease. Hypertriglyceridaemia, absence of α and pre β bands on the lipoprotein electrophoresis pattern, low level of Apo A, and presence of abnormal lipoproteins (β-VLDL and β2-LP) were observed in the early phase of acute hepatitis. A positive correlation was found between Apo A and high-density lipoprotein cholesterol, and a negative one between Apo A and triglyceride, bile acids, total bilirubin, and serum alanine aminotransferase. Lipoprotein abnormalities in the early phase of acute hepatitis are probably due to low lecithin-cholesterol acyltransferase activity. The reappearance of α lipoprotein and the increase of Apo A are sensitive indices of improvement of liver function. In chronic liver disease low levels of cholesterol and Apo A indicate the severity of liver cell injury.
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M3 - Article
C2 - 690242
AN - SCOPUS:0018159446
VL - 31
SP - 772
EP - 778
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 8
ER -