Serum type I and type III procollagen peptide levels in sarcoidosis

L. Bacchella, C. Tinelli, L. S. Gilè, V. Peona, C. Aprile, [No Value] MGorrini, L. Pasturenzi, G. Cetta, M. Luisetti

Research output: Contribution to journalArticlepeer-review

Abstract

Type I and type III are the most abundant collagens in the lung. The aim of our study was to compare type I and III procollagen peptides in sera of sarcoid patients. Sixty eight patients with sarcoidosis were studied (19 with newly recognized disease, 7 with relapsing disease, 15 with chronic disease, and 27 in stable remission). Thirty healthy volunteers served as controls. The levels of procollagen I and III peptides were determined by radioimmunoassay. Angiotensin-converting enzyme (ACE) level was evaluated by means of a colorimetric assay. In patients with newly recognized sarcoidosis, both serum procollagen I and III peptide levels were increased with respect to controls (p=0.0014 and p

Original languageEnglish
Pages (from-to)1648-1651
Number of pages4
JournalEuropean Respiratory Journal
Volume9
Issue number8
Publication statusPublished - 1996

Keywords

  • Angiotensin-converting enzyme
  • Collagens
  • Granulomata
  • Lung
  • Sarcoidosis activity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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