Serum Type III procollagen peptide and laminin (Lam-P1) detect alcoholic hepatitis in chronic alcohol abusers

G. Annoni, M. Colombo, M. C. Cantaluppi, B. Khlat, P. Lampertico, M. Rojkind

Research output: Contribution to journalArticle

Abstract

The diagnosis of alcoholic hepatitis is difficult to establish by conventional clinical and laboratory methods, and a firm diagnosis relies on liver histology. Since there are severe limitations in following patients with repeated liver biopsies, noninvasive procedures are needed to assess the presence of alcoholic hepatitis in chronic alcohol abusers. It has been suggested that serum Type III procollagen peptide levels correlates with the degree of inflammation in chronic liver disease. Since inflammation is a major histological finding in alcoholic hepatitis, we therefore studied the usefulness of measuring serum Type III procollagen peptide and laminin values in 45 consecutive chronic alcohol abusers, with or without cirrhosis, in detecting those with alcoholic hepatitis. The results showed that both Type III procollagen peptide and laminin values were elevated in all of the patients with established liver damage. However, the values were highest in those with liver cirrhosis plus alcoholic hepatitis Type III procollagen peptide 50.4 ± 36.4 ng per ml vs. 8.1 ± 2.6 in controls, p <0.01; laminin 4.50 ± 1.49 units per liter vs. 1.24 ± 0.26 units per liter in controls, p <0.01), followed by subjects with alcoholic hepatitis alone (Type III procollagen peptide 23.5 ± 17.6 ng per ml p <0.01; laminin 2.60 ± 1.09 units per liter, p <0.01). Whereas Type III procollagen peptide values did not discriminate among patients with cirrhosis (21.5 ± 10.1 ng per ml) and those with steatofibrosis (14.3 ± 3.2 ng per ml), nor among those with alcoholic hepatitis and those with steatofibrosis, laminin values did (respectively, 2.12 ± 0.60 units per liter and 1.42 ± 0.41 units per liter, p <0.01). We thus suggest that independently of whether Type III procollagen peptide or laminin serum values reflect increased deposition or breakdown of extracellular matrix components, they are useful in recognizing alcoholic hepatitis patients.

Original languageEnglish
Pages (from-to)693-697
Number of pages5
JournalHepatology
Volume9
Issue number5
Publication statusPublished - 1989

Fingerprint

Alcoholic Hepatitis
Collagen Type III
Laminin
Alcohols
Peptides
Serum
Liver
Fibrosis
Inflammation
laminin P1
Liver Cirrhosis
Extracellular Matrix
Liver Diseases
Histology
Chronic Disease
Biopsy

ASJC Scopus subject areas

  • Hepatology

Cite this

Serum Type III procollagen peptide and laminin (Lam-P1) detect alcoholic hepatitis in chronic alcohol abusers. / Annoni, G.; Colombo, M.; Cantaluppi, M. C.; Khlat, B.; Lampertico, P.; Rojkind, M.

In: Hepatology, Vol. 9, No. 5, 1989, p. 693-697.

Research output: Contribution to journalArticle

Annoni, G. ; Colombo, M. ; Cantaluppi, M. C. ; Khlat, B. ; Lampertico, P. ; Rojkind, M. / Serum Type III procollagen peptide and laminin (Lam-P1) detect alcoholic hepatitis in chronic alcohol abusers. In: Hepatology. 1989 ; Vol. 9, No. 5. pp. 693-697.
@article{2be301c30ccd4d98b05aee51e0b4067c,
title = "Serum Type III procollagen peptide and laminin (Lam-P1) detect alcoholic hepatitis in chronic alcohol abusers",
abstract = "The diagnosis of alcoholic hepatitis is difficult to establish by conventional clinical and laboratory methods, and a firm diagnosis relies on liver histology. Since there are severe limitations in following patients with repeated liver biopsies, noninvasive procedures are needed to assess the presence of alcoholic hepatitis in chronic alcohol abusers. It has been suggested that serum Type III procollagen peptide levels correlates with the degree of inflammation in chronic liver disease. Since inflammation is a major histological finding in alcoholic hepatitis, we therefore studied the usefulness of measuring serum Type III procollagen peptide and laminin values in 45 consecutive chronic alcohol abusers, with or without cirrhosis, in detecting those with alcoholic hepatitis. The results showed that both Type III procollagen peptide and laminin values were elevated in all of the patients with established liver damage. However, the values were highest in those with liver cirrhosis plus alcoholic hepatitis Type III procollagen peptide 50.4 ± 36.4 ng per ml vs. 8.1 ± 2.6 in controls, p <0.01; laminin 4.50 ± 1.49 units per liter vs. 1.24 ± 0.26 units per liter in controls, p <0.01), followed by subjects with alcoholic hepatitis alone (Type III procollagen peptide 23.5 ± 17.6 ng per ml p <0.01; laminin 2.60 ± 1.09 units per liter, p <0.01). Whereas Type III procollagen peptide values did not discriminate among patients with cirrhosis (21.5 ± 10.1 ng per ml) and those with steatofibrosis (14.3 ± 3.2 ng per ml), nor among those with alcoholic hepatitis and those with steatofibrosis, laminin values did (respectively, 2.12 ± 0.60 units per liter and 1.42 ± 0.41 units per liter, p <0.01). We thus suggest that independently of whether Type III procollagen peptide or laminin serum values reflect increased deposition or breakdown of extracellular matrix components, they are useful in recognizing alcoholic hepatitis patients.",
author = "G. Annoni and M. Colombo and Cantaluppi, {M. C.} and B. Khlat and P. Lampertico and M. Rojkind",
year = "1989",
language = "English",
volume = "9",
pages = "693--697",
journal = "Hepatology",
issn = "0270-9139",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Serum Type III procollagen peptide and laminin (Lam-P1) detect alcoholic hepatitis in chronic alcohol abusers

AU - Annoni, G.

AU - Colombo, M.

AU - Cantaluppi, M. C.

AU - Khlat, B.

AU - Lampertico, P.

AU - Rojkind, M.

PY - 1989

Y1 - 1989

N2 - The diagnosis of alcoholic hepatitis is difficult to establish by conventional clinical and laboratory methods, and a firm diagnosis relies on liver histology. Since there are severe limitations in following patients with repeated liver biopsies, noninvasive procedures are needed to assess the presence of alcoholic hepatitis in chronic alcohol abusers. It has been suggested that serum Type III procollagen peptide levels correlates with the degree of inflammation in chronic liver disease. Since inflammation is a major histological finding in alcoholic hepatitis, we therefore studied the usefulness of measuring serum Type III procollagen peptide and laminin values in 45 consecutive chronic alcohol abusers, with or without cirrhosis, in detecting those with alcoholic hepatitis. The results showed that both Type III procollagen peptide and laminin values were elevated in all of the patients with established liver damage. However, the values were highest in those with liver cirrhosis plus alcoholic hepatitis Type III procollagen peptide 50.4 ± 36.4 ng per ml vs. 8.1 ± 2.6 in controls, p <0.01; laminin 4.50 ± 1.49 units per liter vs. 1.24 ± 0.26 units per liter in controls, p <0.01), followed by subjects with alcoholic hepatitis alone (Type III procollagen peptide 23.5 ± 17.6 ng per ml p <0.01; laminin 2.60 ± 1.09 units per liter, p <0.01). Whereas Type III procollagen peptide values did not discriminate among patients with cirrhosis (21.5 ± 10.1 ng per ml) and those with steatofibrosis (14.3 ± 3.2 ng per ml), nor among those with alcoholic hepatitis and those with steatofibrosis, laminin values did (respectively, 2.12 ± 0.60 units per liter and 1.42 ± 0.41 units per liter, p <0.01). We thus suggest that independently of whether Type III procollagen peptide or laminin serum values reflect increased deposition or breakdown of extracellular matrix components, they are useful in recognizing alcoholic hepatitis patients.

AB - The diagnosis of alcoholic hepatitis is difficult to establish by conventional clinical and laboratory methods, and a firm diagnosis relies on liver histology. Since there are severe limitations in following patients with repeated liver biopsies, noninvasive procedures are needed to assess the presence of alcoholic hepatitis in chronic alcohol abusers. It has been suggested that serum Type III procollagen peptide levels correlates with the degree of inflammation in chronic liver disease. Since inflammation is a major histological finding in alcoholic hepatitis, we therefore studied the usefulness of measuring serum Type III procollagen peptide and laminin values in 45 consecutive chronic alcohol abusers, with or without cirrhosis, in detecting those with alcoholic hepatitis. The results showed that both Type III procollagen peptide and laminin values were elevated in all of the patients with established liver damage. However, the values were highest in those with liver cirrhosis plus alcoholic hepatitis Type III procollagen peptide 50.4 ± 36.4 ng per ml vs. 8.1 ± 2.6 in controls, p <0.01; laminin 4.50 ± 1.49 units per liter vs. 1.24 ± 0.26 units per liter in controls, p <0.01), followed by subjects with alcoholic hepatitis alone (Type III procollagen peptide 23.5 ± 17.6 ng per ml p <0.01; laminin 2.60 ± 1.09 units per liter, p <0.01). Whereas Type III procollagen peptide values did not discriminate among patients with cirrhosis (21.5 ± 10.1 ng per ml) and those with steatofibrosis (14.3 ± 3.2 ng per ml), nor among those with alcoholic hepatitis and those with steatofibrosis, laminin values did (respectively, 2.12 ± 0.60 units per liter and 1.42 ± 0.41 units per liter, p <0.01). We thus suggest that independently of whether Type III procollagen peptide or laminin serum values reflect increased deposition or breakdown of extracellular matrix components, they are useful in recognizing alcoholic hepatitis patients.

UR - http://www.scopus.com/inward/record.url?scp=0024602133&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024602133&partnerID=8YFLogxK

M3 - Article

C2 - 2707736

AN - SCOPUS:0024602133

VL - 9

SP - 693

EP - 697

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 5

ER -