TY - JOUR
T1 - Serum type III procollagen peptide in alcoholic liver disease and idiopathic hemochromatosis
T2 - Its relationship to hepatic fibrosis, activity of the disease and iron overload
AU - Colombo, M.
AU - Annoni, G.
AU - Donato, M. F.
AU - Conte, D.
AU - Martines, D.
AU - Zaramella, M. G.
AU - Bianchi, P. A.
AU - Piperno, A.
AU - Tiribelli, C.
PY - 1985
Y1 - 1985
N2 - To assess the value of type III procollagen peptide (sPIIIP) as a marker of hepatic fibrosis, sera from 73 patients with alcohol-related liver disease and 30 patients with idiopathic hemochromatosis (IHC) were studied by a specific radioimmunoassay. sPIIIP was increased in 87% of 30 patients with cirrhosis, in 16% of 32 with steatofibrosis but in none of 11 with steatosis. There was a significant correlation with histological hepatocellular necroinflammation (r = 0.42, p <0.01), but not with hepatic fibrosis. sPIIIP was increased in 33% of 30 patients with IHC, whether or not they had cirrhosis or fibrosis, and whatever the level of iron overload or the extent of the hepatic deterioration. IHC patients with increased levels of sPIIIP had a higher prevalence of superimposed hepatic damage than did those with normal procollagen levels (p <0.05). Our findings, therefore, weaken the diagnostic value of sPIIIP as an index of connective tissue deposition in the liver, and suggest that, at least in alcohol-related liver disease and IHC, hepatocellular necroinflammation influences the results.
AB - To assess the value of type III procollagen peptide (sPIIIP) as a marker of hepatic fibrosis, sera from 73 patients with alcohol-related liver disease and 30 patients with idiopathic hemochromatosis (IHC) were studied by a specific radioimmunoassay. sPIIIP was increased in 87% of 30 patients with cirrhosis, in 16% of 32 with steatofibrosis but in none of 11 with steatosis. There was a significant correlation with histological hepatocellular necroinflammation (r = 0.42, p <0.01), but not with hepatic fibrosis. sPIIIP was increased in 33% of 30 patients with IHC, whether or not they had cirrhosis or fibrosis, and whatever the level of iron overload or the extent of the hepatic deterioration. IHC patients with increased levels of sPIIIP had a higher prevalence of superimposed hepatic damage than did those with normal procollagen levels (p <0.05). Our findings, therefore, weaken the diagnostic value of sPIIIP as an index of connective tissue deposition in the liver, and suggest that, at least in alcohol-related liver disease and IHC, hepatocellular necroinflammation influences the results.
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U2 - 10.1002/hep.1840050322
DO - 10.1002/hep.1840050322
M3 - Article
C2 - 3997075
AN - SCOPUS:0021878774
VL - 5
SP - 475
EP - 479
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 3
ER -