Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study

Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men.

METHODS: The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18-95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 ± 66.9 months.

RESULTS: A total of 23 467 individuals were included in the analysis. Cut-off values of SUA able to discriminate MI status were identified by mean of receiver operating characteristic curves in the whole database (>5.70 mg/dl), in women (>5.26 mg/dl) and in men (>5.49 mg/dl). Multivariate Cox regression analyses adjusted for confounders (age, arterial hypertension, diabetes, chronic kidney disease, smoking habit, ethanol intake, BMI, haematocrit, LDL cholesterol and use of diuretics) identified an independent association between SUA and fatal MI in the whole database (hazard ratio 1.381, 95% confidence intervals, 1.096-1.758, P = 0.006) and in women (hazard ratio 1.514, confidence intervals 1.105-2.075, P < 0.01), but not in men.

CONCLUSION: The results of the current study confirm that SUA is an independent risk factor for fatal MI after adjusting for potential confounding variables, and demonstrate that a prognostic cut-off value associated to fatal MI can be identified at least in women.

Original languageEnglish
JournalJournal of Hypertension
DOIs
Publication statusE-pub ahead of print - Oct 21 2019

Cite this

Serum uric acid and fatal myocardial infarction : detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study. / Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA).

In: Journal of Hypertension, 21.10.2019.

Research output: Contribution to journalArticle

Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA). / Serum uric acid and fatal myocardial infarction : detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study. In: Journal of Hypertension. 2019.
@article{93babf52ab4b475eacaa384dd11aee8b,
title = "Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study",
abstract = "OBJECTIVE: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men.METHODS: The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18-95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 ± 66.9 months.RESULTS: A total of 23 467 individuals were included in the analysis. Cut-off values of SUA able to discriminate MI status were identified by mean of receiver operating characteristic curves in the whole database (>5.70 mg/dl), in women (>5.26 mg/dl) and in men (>5.49 mg/dl). Multivariate Cox regression analyses adjusted for confounders (age, arterial hypertension, diabetes, chronic kidney disease, smoking habit, ethanol intake, BMI, haematocrit, LDL cholesterol and use of diuretics) identified an independent association between SUA and fatal MI in the whole database (hazard ratio 1.381, 95{\%} confidence intervals, 1.096-1.758, P = 0.006) and in women (hazard ratio 1.514, confidence intervals 1.105-2.075, P < 0.01), but not in men.CONCLUSION: The results of the current study confirm that SUA is an independent risk factor for fatal MI after adjusting for potential confounding variables, and demonstrate that a prognostic cut-off value associated to fatal MI can be identified at least in women.",
author = "{Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)} and Edoardo Casiglia and Val{\'e}rie Tikhonoff and Agostino Virdis and Stefano Masi and Barbagallo, {Carlo M} and Michele Bombelli and Bernardino Bruno and Cicero, {Arrigo F G} and Massimo Cirillo and Pietro Cirillo and Giovambattista Desideri and Lanfranco D'Elia and Claudio Ferri and Ferruccio Galletti and Loreto Gesualdo and Cristina Giannattasio and Guido Iaccarino and Luciano Lippa and Francesca Mallamaci and Alessandro Maloberti and Alberto Mazza and Muiesan, {Maria Lorenza} and Pietro Nazzaro and Paolo Palatini and Gianfranco Parati and Roberto Pontremoli and Fosca Quarti-Trevano and Marcello Rattazzi and Giulia Rivasi and Massimo Salvetti and Giuliano Tocci and Andrea Ungar and Paolo Verdecchia and Francesca Viazzi and Massimo Volpe and Guido Grassi and Claudio Borghi",
year = "2019",
month = "10",
day = "21",
doi = "10.1097/HJH.0000000000002287",
language = "English",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Serum uric acid and fatal myocardial infarction

T2 - detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study

AU - Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

AU - Casiglia, Edoardo

AU - Tikhonoff, Valérie

AU - Virdis, Agostino

AU - Masi, Stefano

AU - Barbagallo, Carlo M

AU - Bombelli, Michele

AU - Bruno, Bernardino

AU - Cicero, Arrigo F G

AU - Cirillo, Massimo

AU - Cirillo, Pietro

AU - Desideri, Giovambattista

AU - D'Elia, Lanfranco

AU - Ferri, Claudio

AU - Galletti, Ferruccio

AU - Gesualdo, Loreto

AU - Giannattasio, Cristina

AU - Iaccarino, Guido

AU - Lippa, Luciano

AU - Mallamaci, Francesca

AU - Maloberti, Alessandro

AU - Mazza, Alberto

AU - Muiesan, Maria Lorenza

AU - Nazzaro, Pietro

AU - Palatini, Paolo

AU - Parati, Gianfranco

AU - Pontremoli, Roberto

AU - Quarti-Trevano, Fosca

AU - Rattazzi, Marcello

AU - Rivasi, Giulia

AU - Salvetti, Massimo

AU - Tocci, Giuliano

AU - Ungar, Andrea

AU - Verdecchia, Paolo

AU - Viazzi, Francesca

AU - Volpe, Massimo

AU - Grassi, Guido

AU - Borghi, Claudio

PY - 2019/10/21

Y1 - 2019/10/21

N2 - OBJECTIVE: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men.METHODS: The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18-95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 ± 66.9 months.RESULTS: A total of 23 467 individuals were included in the analysis. Cut-off values of SUA able to discriminate MI status were identified by mean of receiver operating characteristic curves in the whole database (>5.70 mg/dl), in women (>5.26 mg/dl) and in men (>5.49 mg/dl). Multivariate Cox regression analyses adjusted for confounders (age, arterial hypertension, diabetes, chronic kidney disease, smoking habit, ethanol intake, BMI, haematocrit, LDL cholesterol and use of diuretics) identified an independent association between SUA and fatal MI in the whole database (hazard ratio 1.381, 95% confidence intervals, 1.096-1.758, P = 0.006) and in women (hazard ratio 1.514, confidence intervals 1.105-2.075, P < 0.01), but not in men.CONCLUSION: The results of the current study confirm that SUA is an independent risk factor for fatal MI after adjusting for potential confounding variables, and demonstrate that a prognostic cut-off value associated to fatal MI can be identified at least in women.

AB - OBJECTIVE: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men.METHODS: The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18-95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 ± 66.9 months.RESULTS: A total of 23 467 individuals were included in the analysis. Cut-off values of SUA able to discriminate MI status were identified by mean of receiver operating characteristic curves in the whole database (>5.70 mg/dl), in women (>5.26 mg/dl) and in men (>5.49 mg/dl). Multivariate Cox regression analyses adjusted for confounders (age, arterial hypertension, diabetes, chronic kidney disease, smoking habit, ethanol intake, BMI, haematocrit, LDL cholesterol and use of diuretics) identified an independent association between SUA and fatal MI in the whole database (hazard ratio 1.381, 95% confidence intervals, 1.096-1.758, P = 0.006) and in women (hazard ratio 1.514, confidence intervals 1.105-2.075, P < 0.01), but not in men.CONCLUSION: The results of the current study confirm that SUA is an independent risk factor for fatal MI after adjusting for potential confounding variables, and demonstrate that a prognostic cut-off value associated to fatal MI can be identified at least in women.

U2 - 10.1097/HJH.0000000000002287

DO - 10.1097/HJH.0000000000002287

M3 - Article

C2 - 31644519

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

ER -