Serum uric acid and hypertension: The Olivetti heart study

F. Jossa, E. Farinaro, S. Panico, V. Krogh, E. Celentano, R. Galasso, M. Mancini, M. Trevisan

Research output: Contribution to journalArticle

Abstract

The association between serum uric acid and hypertension was evaluated in a sample of male workers in southern Italy enrolled in the Olivetti Heart Study, an ongoing longitudinal epidemiological investigation on risk factors for coronary heart disease carried out at the Olivetti factory in the suburban area of Naples. Participants were screened at baseline (1975) and at five year (1980) and 12 year (1987) follow-up examinations. The present report focuses on 619 male workers for whom information on coronary heart disease risk factors was available both at baseline and 12 year follow-up examination. At baseline, after excluding hypertensive participants (systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP), ≥ 90 mmHg and/or on antihypertensive therapy; n = 72), serum uric acid was positively and significantly related to age, SBP, DBP, body mass index (BMI), serum total cholesterol (CHOL) and serum triglycerides (TG) in 547 normotensive participants. At 12 year follow-up examination, hypertension was defined by SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg and/or being on antihypertensive therapy. Multiple logistic regression analysis showed an independent positive association between serum uric acid levels and development of hypertension (RR = 1.23, 95% CI = 1.07-1.39; p = 0.011) after adjustment for age, BMI, CHOL and TG. Furthermore, according to more severe degrees of hypertension (SBP ≥ 160 mmHg and/or DBP ≥ 95 mmHg and/or being on antihypertensive therapy), the relative risk to develop hypertension was still significant (RR = 1.19; CI = 1.01-1.38; p = 0.051). These longitudinal data indicate that high levels of serum uric acid may be associated with hypertension.

Original languageEnglish
Pages (from-to)677-681
Number of pages5
JournalJournal of Human Hypertension
Volume8
Issue number9
Publication statusPublished - 1994

Fingerprint

Uric Acid
Blood Pressure
Hypertension
Serum
Antihypertensive Agents
Coronary Disease
Triglycerides
Body Mass Index
Cholesterol
Italy
Longitudinal Studies

Keywords

  • Blood pressure
  • Hypertension
  • Serum uric acid

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Jossa, F., Farinaro, E., Panico, S., Krogh, V., Celentano, E., Galasso, R., ... Trevisan, M. (1994). Serum uric acid and hypertension: The Olivetti heart study. Journal of Human Hypertension, 8(9), 677-681.

Serum uric acid and hypertension : The Olivetti heart study. / Jossa, F.; Farinaro, E.; Panico, S.; Krogh, V.; Celentano, E.; Galasso, R.; Mancini, M.; Trevisan, M.

In: Journal of Human Hypertension, Vol. 8, No. 9, 1994, p. 677-681.

Research output: Contribution to journalArticle

Jossa, F, Farinaro, E, Panico, S, Krogh, V, Celentano, E, Galasso, R, Mancini, M & Trevisan, M 1994, 'Serum uric acid and hypertension: The Olivetti heart study', Journal of Human Hypertension, vol. 8, no. 9, pp. 677-681.
Jossa F, Farinaro E, Panico S, Krogh V, Celentano E, Galasso R et al. Serum uric acid and hypertension: The Olivetti heart study. Journal of Human Hypertension. 1994;8(9):677-681.
Jossa, F. ; Farinaro, E. ; Panico, S. ; Krogh, V. ; Celentano, E. ; Galasso, R. ; Mancini, M. ; Trevisan, M. / Serum uric acid and hypertension : The Olivetti heart study. In: Journal of Human Hypertension. 1994 ; Vol. 8, No. 9. pp. 677-681.
@article{3db50645dfbd4763b1381b70fe0cda9e,
title = "Serum uric acid and hypertension: The Olivetti heart study",
abstract = "The association between serum uric acid and hypertension was evaluated in a sample of male workers in southern Italy enrolled in the Olivetti Heart Study, an ongoing longitudinal epidemiological investigation on risk factors for coronary heart disease carried out at the Olivetti factory in the suburban area of Naples. Participants were screened at baseline (1975) and at five year (1980) and 12 year (1987) follow-up examinations. The present report focuses on 619 male workers for whom information on coronary heart disease risk factors was available both at baseline and 12 year follow-up examination. At baseline, after excluding hypertensive participants (systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP), ≥ 90 mmHg and/or on antihypertensive therapy; n = 72), serum uric acid was positively and significantly related to age, SBP, DBP, body mass index (BMI), serum total cholesterol (CHOL) and serum triglycerides (TG) in 547 normotensive participants. At 12 year follow-up examination, hypertension was defined by SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg and/or being on antihypertensive therapy. Multiple logistic regression analysis showed an independent positive association between serum uric acid levels and development of hypertension (RR = 1.23, 95{\%} CI = 1.07-1.39; p = 0.011) after adjustment for age, BMI, CHOL and TG. Furthermore, according to more severe degrees of hypertension (SBP ≥ 160 mmHg and/or DBP ≥ 95 mmHg and/or being on antihypertensive therapy), the relative risk to develop hypertension was still significant (RR = 1.19; CI = 1.01-1.38; p = 0.051). These longitudinal data indicate that high levels of serum uric acid may be associated with hypertension.",
keywords = "Blood pressure, Hypertension, Serum uric acid",
author = "F. Jossa and E. Farinaro and S. Panico and V. Krogh and E. Celentano and R. Galasso and M. Mancini and M. Trevisan",
year = "1994",
language = "English",
volume = "8",
pages = "677--681",
journal = "Journal of Human Hypertension",
issn = "0950-9240",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Serum uric acid and hypertension

T2 - The Olivetti heart study

AU - Jossa, F.

AU - Farinaro, E.

AU - Panico, S.

AU - Krogh, V.

AU - Celentano, E.

AU - Galasso, R.

AU - Mancini, M.

AU - Trevisan, M.

PY - 1994

Y1 - 1994

N2 - The association between serum uric acid and hypertension was evaluated in a sample of male workers in southern Italy enrolled in the Olivetti Heart Study, an ongoing longitudinal epidemiological investigation on risk factors for coronary heart disease carried out at the Olivetti factory in the suburban area of Naples. Participants were screened at baseline (1975) and at five year (1980) and 12 year (1987) follow-up examinations. The present report focuses on 619 male workers for whom information on coronary heart disease risk factors was available both at baseline and 12 year follow-up examination. At baseline, after excluding hypertensive participants (systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP), ≥ 90 mmHg and/or on antihypertensive therapy; n = 72), serum uric acid was positively and significantly related to age, SBP, DBP, body mass index (BMI), serum total cholesterol (CHOL) and serum triglycerides (TG) in 547 normotensive participants. At 12 year follow-up examination, hypertension was defined by SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg and/or being on antihypertensive therapy. Multiple logistic regression analysis showed an independent positive association between serum uric acid levels and development of hypertension (RR = 1.23, 95% CI = 1.07-1.39; p = 0.011) after adjustment for age, BMI, CHOL and TG. Furthermore, according to more severe degrees of hypertension (SBP ≥ 160 mmHg and/or DBP ≥ 95 mmHg and/or being on antihypertensive therapy), the relative risk to develop hypertension was still significant (RR = 1.19; CI = 1.01-1.38; p = 0.051). These longitudinal data indicate that high levels of serum uric acid may be associated with hypertension.

AB - The association between serum uric acid and hypertension was evaluated in a sample of male workers in southern Italy enrolled in the Olivetti Heart Study, an ongoing longitudinal epidemiological investigation on risk factors for coronary heart disease carried out at the Olivetti factory in the suburban area of Naples. Participants were screened at baseline (1975) and at five year (1980) and 12 year (1987) follow-up examinations. The present report focuses on 619 male workers for whom information on coronary heart disease risk factors was available both at baseline and 12 year follow-up examination. At baseline, after excluding hypertensive participants (systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP), ≥ 90 mmHg and/or on antihypertensive therapy; n = 72), serum uric acid was positively and significantly related to age, SBP, DBP, body mass index (BMI), serum total cholesterol (CHOL) and serum triglycerides (TG) in 547 normotensive participants. At 12 year follow-up examination, hypertension was defined by SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg and/or being on antihypertensive therapy. Multiple logistic regression analysis showed an independent positive association between serum uric acid levels and development of hypertension (RR = 1.23, 95% CI = 1.07-1.39; p = 0.011) after adjustment for age, BMI, CHOL and TG. Furthermore, according to more severe degrees of hypertension (SBP ≥ 160 mmHg and/or DBP ≥ 95 mmHg and/or being on antihypertensive therapy), the relative risk to develop hypertension was still significant (RR = 1.19; CI = 1.01-1.38; p = 0.051). These longitudinal data indicate that high levels of serum uric acid may be associated with hypertension.

KW - Blood pressure

KW - Hypertension

KW - Serum uric acid

UR - http://www.scopus.com/inward/record.url?scp=0027968722&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027968722&partnerID=8YFLogxK

M3 - Article

C2 - 7807497

AN - SCOPUS:0027968722

VL - 8

SP - 677

EP - 681

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 9

ER -