Serum uric acid and other short-term predictors of electrocardiographic alterations in the Brisighella Heart Study cohort

Arrigo F G Cicero, Martina Rosticci, Giuliano Tocci, Stefano Bacchelli, Riccado Urso, Sergio D'Addato, Claudio Borghi

Research output: Contribution to journalArticle

Abstract

Introduction: Recent studies show that serum uric acid (SUA) is a predictor of atrial fibrillation, while its association with other kinds of arrhythmias is not yet established. We aimed to evaluate the incidence of the most common electrocardiographic alterations in a relatively large sample of general population and their association with SUA. Materials and methods: We selected a Brisighella Heart Study cohort sample of 1557 subjects, consecutively visited in the 2004 and 2008 surveys, in a setting of primary prevention for cardiovascular disease and without a known diagnosis of arrhythmia or left ventricular hypertrophy, excluding subjects affected by gout or taking any antihyperuricemic agent or drugs able to interfere with the QT interval. A step-wise Cox regression analysis was used to determine the independent prognostic significance of age, gender, physical activity, smoking, body mass index (BMI), fasting plasma glucose, mean arterial pressure (MAP), heart rate, LDL-cholesterol, HDL-cholesterol, triglycerides, SUA and eGFR on ECG alterations during a 4-year follow-up. Results: No one of the considered variables was associated with the incident diagnosis of sinus tachycardia and sinus bradycardia. SUA predicted incident tachyarrhythmias, Q waves and ECG signs of left ventricular hypertrophy; age, female sex and active smoking predicted incident tachyarrhythmias; male sex, active smoking and LDL-cholesterol predicted incident ECG signs of previous myocardial infarction; BMI and MAP predicted incident ECG-diagnosed left ventricular hypertrophy. Conclusion: In a cohort of general population, SUA seems to be a significant middle-term predictor of electrocardiographically diagnosed myocardial infarction, left ventricular hypertrophy and tachyarrhythmias.

Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalEuropean Journal of Internal Medicine
Volume26
Issue number4
DOIs
Publication statusPublished - May 1 2015

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Uric Acid
Left Ventricular Hypertrophy
Cohort Studies
Electrocardiography
Tachycardia
Serum
Smoking
LDL Cholesterol
Gout Suppressants
Cardiac Arrhythmias
Arterial Pressure
Body Mass Index
Myocardial Infarction
Sinus Tachycardia
Gout
Primary Prevention
Bradycardia
Atrial Fibrillation
HDL Cholesterol
Population

Keywords

  • Arrhythmias
  • Electrocardiogram
  • Epidemiology
  • Serum uric acid

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Serum uric acid and other short-term predictors of electrocardiographic alterations in the Brisighella Heart Study cohort. / Cicero, Arrigo F G; Rosticci, Martina; Tocci, Giuliano; Bacchelli, Stefano; Urso, Riccado; D'Addato, Sergio; Borghi, Claudio.

In: European Journal of Internal Medicine, Vol. 26, No. 4, 01.05.2015, p. 255-258.

Research output: Contribution to journalArticle

Cicero, Arrigo F G ; Rosticci, Martina ; Tocci, Giuliano ; Bacchelli, Stefano ; Urso, Riccado ; D'Addato, Sergio ; Borghi, Claudio. / Serum uric acid and other short-term predictors of electrocardiographic alterations in the Brisighella Heart Study cohort. In: European Journal of Internal Medicine. 2015 ; Vol. 26, No. 4. pp. 255-258.
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AB - Introduction: Recent studies show that serum uric acid (SUA) is a predictor of atrial fibrillation, while its association with other kinds of arrhythmias is not yet established. We aimed to evaluate the incidence of the most common electrocardiographic alterations in a relatively large sample of general population and their association with SUA. Materials and methods: We selected a Brisighella Heart Study cohort sample of 1557 subjects, consecutively visited in the 2004 and 2008 surveys, in a setting of primary prevention for cardiovascular disease and without a known diagnosis of arrhythmia or left ventricular hypertrophy, excluding subjects affected by gout or taking any antihyperuricemic agent or drugs able to interfere with the QT interval. A step-wise Cox regression analysis was used to determine the independent prognostic significance of age, gender, physical activity, smoking, body mass index (BMI), fasting plasma glucose, mean arterial pressure (MAP), heart rate, LDL-cholesterol, HDL-cholesterol, triglycerides, SUA and eGFR on ECG alterations during a 4-year follow-up. Results: No one of the considered variables was associated with the incident diagnosis of sinus tachycardia and sinus bradycardia. SUA predicted incident tachyarrhythmias, Q waves and ECG signs of left ventricular hypertrophy; age, female sex and active smoking predicted incident tachyarrhythmias; male sex, active smoking and LDL-cholesterol predicted incident ECG signs of previous myocardial infarction; BMI and MAP predicted incident ECG-diagnosed left ventricular hypertrophy. Conclusion: In a cohort of general population, SUA seems to be a significant middle-term predictor of electrocardiographically diagnosed myocardial infarction, left ventricular hypertrophy and tachyarrhythmias.

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