Elevated serum uric acid concentrations have been observed in clinical conditions associated with hypoxia. Since chronic heart failure (CHF) is a state of unpaired oxidative metabolism, we sought to determine whether serum uric acid concentrations relate to measures of functional capacity and disease severity. Methods: Patients with CHF (n=59) and healthy controls (n=20) underwent assessment of maximal oxygen consumption (MVO2) and regression slope relating to minute ventilation to carbon dioxide output (VE-VCO2) during a maximal treadmill exercise test. A metabolic assessment included measurement of serum uric acid and insulin sensitivity (obtained by minimal modelling analysis of glucose and insulin responses during an intravenous glucose tolerance test). Results: Compared to controls, patients with CHF had a 52% lower MVO2, 56.8% higher serum uric acid concentrations, and a 60.5% lower insulin sensitivity (all p2 (r=-0.50) (both p2 (r=0.45) and NYHA class (r=0.36) (both p2, exercise time (both p2 and NYHA class (both p2 suggests that in CHF, serum uric acid concentrations can provide an index of an impairment of oxidative metabolism.
|Issue number||SUPPL. 1|
|Publication status||Published - May 1997|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine