Serum uric acid as a marker of impaired oxidative metabolism in chronic heart failure

F. Leyva, S. D. Anker, T. P. Chua, I. F. Godsland, J. C. Stevenson, A. J S Coats

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Elevated serum uric acid concentrations have been observed in clinical conditions associated with hypoxia. Since chronic heart failure (CHF) is a state of unpaired oxidative metabolism, we sought to determine whether serum uric acid concentrations relate to measures of functional capacity and disease severity. Methods: Patients with CHF (n=59) and healthy controls (n=20) underwent assessment of maximal oxygen consumption (MVO2) and regression slope relating to minute ventilation to carbon dioxide output (VE-VCO2) during a maximal treadmill exercise test. A metabolic assessment included measurement of serum uric acid and insulin sensitivity (obtained by minimal modelling analysis of glucose and insulin responses during an intravenous glucose tolerance test). Results: Compared to controls, patients with CHF had a 52% lower MVO2, 56.8% higher serum uric acid concentrations, and a 60.5% lower insulin sensitivity (all p2 (r=-0.50) (both p2 (r=0.45) and NYHA class (r=0.36) (both p2, exercise time (both p2 and NYHA class (both p2 suggests that in CHF, serum uric acid concentrations can provide an index of an impairment of oxidative metabolism.

Original languageEnglish
Issue numberSUPPL. 1
Publication statusPublished - May 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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