Serum uric acid as a prognostic marker in the setting of advanced vascular disease: A prospective study in the elderly

Giuseppe Di Stolfo, Sandra Mastroianno, Domenico Rosario Potenza, Giovanni De Luca, Carmela D'Arienzo, Michele Antonio Pacilli, Mario Fanelli, Aldo Russo, Raffaele Fanelli

Research output: Contribution to journalArticle

Abstract

Background: Many epidemiological studies analyze the relationship between hyperuricemia and cardiovascular outcomes. This observational prospective study investigates the association of serum uric acid (SUA) levels with adverse cardiovascular events and deaths in an elderly population affected by advanced atherosclerosis. Methods: Two hundred and seventy six elderly patients affected by advanced atherosclerosis (217 males and 59 females; aged 71.2 ± 7.8 years) were included. All patients were assessed for history of cardiovascular disease, cancer, obesity and traditional risk factors. Patients were followed for approximately 31 ± 11 months. Major events were recorded during follow-up, defined as myocardial infarction, cerebral ischemia, myocardial and/or peripheral revascularization and death. Results: Mean SUA level was 5.47 ± 1.43 mg/dL; then we further divided the population in two groups, according to the median value (5.36 mg/dL). During a median follow up of 31 months (5 to 49 months), 66 cardiovascular events, 9 fatal cardiovascular events and 14 cancer-related deaths have occurred. The patients with increased SUA level presented a higher significant incidence of total cardiovascular events (HR: 1.867, P = 0.014, 95% CI: 1.134-3.074). The same patients showed a significant increased risk of cancer-related death (HR: 4.335, P = 0.025, 95% CI: 1.204-15.606). Conclusions: Increased SUA levels are independently and significantly associated with risk of cardiovascular events and cancer related death in a population of mainly elderly patients affected by peripheral vasculopathy.

Original languageEnglish
Pages (from-to)515-520
Number of pages6
JournalJournal of Geriatric Cardiology
Volume12
Issue number5
DOIs
Publication statusPublished - 2015

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Keywords

  • Cardiovascular events
  • Peripheral artery disease
  • Uric acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Geriatrics and Gerontology

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