Serum uric acid is related to markers of immune activation in chronic heart failure

F. Leyva, S. D. Anker, W. J. Kox, I. F. Godsland, P. A. Poole-Wilson, A. J S Coats

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Abstract

Chronic heart failure (CHF) is associated with elevations in circulating uric acid and markers of immune activation. In view of the link between xanthine oxidase activity and leukocyte activation at the level of the capillary endothelium, we sought to determine whether serum uric acid is related to markers of immune activation in patients with CHF, taking into account the hyperuricemic effects of diuretic therapy and insulin resistance. Methods: Circulating uric acid and measures of immune activation were measured in 44 male patients with CHF and 16 healthy controls. All patients underwent a metabolic assessment, which provided an insulin sensitivity index (obtained by minimal modelling analysis of glucose and insulin responses during an intravenous glucose tolerance test). Results: Compared to controls, patients with CHF had significantly higher levels of circulating uric acid, interleukin (IL)-6, soluble tumour necrosis factor receptor (sTNFR)1, soluble intercellular adhesion molecule-1 (sICAM-1), (all p

Original languageEnglish
JournalHeart
Volume77
Issue numberSUPPL. 1
Publication statusPublished - May 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Leyva, F., Anker, S. D., Kox, W. J., Godsland, I. F., Poole-Wilson, P. A., & Coats, A. J. S. (1997). Serum uric acid is related to markers of immune activation in chronic heart failure. Heart, 77(SUPPL. 1).