Abstract
Background and aims: Uric acid (UA) is a byproduct of the high-energy purine metabolism and is conventionally regarded as a marker of cardio-metabolic impairment. Its potential relationship with energy homeostasis is unknown to date. Methods and results: In a cross-sectional study on 121 otherwise healthy obese and 99 sex- and-age-matched lean subjects, UA levels were analyzed in relation to metabolic health, inflammatory markers, respiratory quotient (RQ) and resting energy expenditure (REE) as assessed by indirect calorimetry, fat mass (%FM) and fat-free mass (FFM) as determined by bioimpedance analysis. As expected, obese and lean subjects differed in BMI, glucolipid homeostasis, leptin and insulin levels, inflammatory markers, %FM and FFM (p < 0.001 for all). Likewise, UA levels (p < 0.001) and rates of hyperuricaemia (40.5% vs 3.0%, p < 0.0001) were also higher in obese than lean controls. Further, indirect calorimetry confirmed that obesity increased REE and decreased RQ significantly (p < 0.001). Beyond the expected metabolic correlates, in individual and merged groups UA levels were associated negatively with RQ and positively with REE (p < 0.0001 for both). In multivariable regression analysis, significant independent predictors of UA were BMI and sex. When BMI was replaced by measures of body composition, %FM and FFM emerged as significant predictors of serum UA (p < 0.0001). Conclusions: A potential link relates serum UA to measures of resting energy expenditure and their determinants.
| Original language | English |
|---|---|
| Pages (from-to) | 1029-1035 |
| Number of pages | 7 |
| Journal | Nutrition, Metabolism and Cardiovascular Diseases |
| Volume | 28 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 2018 |
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Keywords
- Obesity
- Respiratory quotient
- Resting energy expenditure
- Uric acid
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
- Cardiology and Cardiovascular Medicine
Cite this
Serum uric acid potentially links metabolic health to measures of fuel use in lean and obese individuals. / Mele, C.; Tagliaferri, M. A.; Saraceno, G.; Mai, S.; Vietti, R.; Zavattaro, M.; Aimaretti, G.; Scacchi, M.; Marzullo, P.
In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 28, No. 10, 01.10.2018, p. 1029-1035.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum uric acid potentially links metabolic health to measures of fuel use in lean and obese individuals
AU - Mele, C.
AU - Tagliaferri, M. A.
AU - Saraceno, G.
AU - Mai, S.
AU - Vietti, R.
AU - Zavattaro, M.
AU - Aimaretti, G.
AU - Scacchi, M.
AU - Marzullo, P.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Background and aims: Uric acid (UA) is a byproduct of the high-energy purine metabolism and is conventionally regarded as a marker of cardio-metabolic impairment. Its potential relationship with energy homeostasis is unknown to date. Methods and results: In a cross-sectional study on 121 otherwise healthy obese and 99 sex- and-age-matched lean subjects, UA levels were analyzed in relation to metabolic health, inflammatory markers, respiratory quotient (RQ) and resting energy expenditure (REE) as assessed by indirect calorimetry, fat mass (%FM) and fat-free mass (FFM) as determined by bioimpedance analysis. As expected, obese and lean subjects differed in BMI, glucolipid homeostasis, leptin and insulin levels, inflammatory markers, %FM and FFM (p < 0.001 for all). Likewise, UA levels (p < 0.001) and rates of hyperuricaemia (40.5% vs 3.0%, p < 0.0001) were also higher in obese than lean controls. Further, indirect calorimetry confirmed that obesity increased REE and decreased RQ significantly (p < 0.001). Beyond the expected metabolic correlates, in individual and merged groups UA levels were associated negatively with RQ and positively with REE (p < 0.0001 for both). In multivariable regression analysis, significant independent predictors of UA were BMI and sex. When BMI was replaced by measures of body composition, %FM and FFM emerged as significant predictors of serum UA (p < 0.0001). Conclusions: A potential link relates serum UA to measures of resting energy expenditure and their determinants.
AB - Background and aims: Uric acid (UA) is a byproduct of the high-energy purine metabolism and is conventionally regarded as a marker of cardio-metabolic impairment. Its potential relationship with energy homeostasis is unknown to date. Methods and results: In a cross-sectional study on 121 otherwise healthy obese and 99 sex- and-age-matched lean subjects, UA levels were analyzed in relation to metabolic health, inflammatory markers, respiratory quotient (RQ) and resting energy expenditure (REE) as assessed by indirect calorimetry, fat mass (%FM) and fat-free mass (FFM) as determined by bioimpedance analysis. As expected, obese and lean subjects differed in BMI, glucolipid homeostasis, leptin and insulin levels, inflammatory markers, %FM and FFM (p < 0.001 for all). Likewise, UA levels (p < 0.001) and rates of hyperuricaemia (40.5% vs 3.0%, p < 0.0001) were also higher in obese than lean controls. Further, indirect calorimetry confirmed that obesity increased REE and decreased RQ significantly (p < 0.001). Beyond the expected metabolic correlates, in individual and merged groups UA levels were associated negatively with RQ and positively with REE (p < 0.0001 for both). In multivariable regression analysis, significant independent predictors of UA were BMI and sex. When BMI was replaced by measures of body composition, %FM and FFM emerged as significant predictors of serum UA (p < 0.0001). Conclusions: A potential link relates serum UA to measures of resting energy expenditure and their determinants.
KW - Obesity
KW - Respiratory quotient
KW - Resting energy expenditure
KW - Uric acid
UR - http://www.scopus.com/inward/record.url?scp=85051748626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051748626&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2018.06.010
DO - 10.1016/j.numecd.2018.06.010
M3 - Article
VL - 28
SP - 1029
EP - 1035
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 10
ER -