Serum, urine and peritoneal fluid levels of 5-FU following intraperitoneal administration

E. Campora, M. Esposito, D. Civalleri, L. Gogioso, F. Decian, N. Balletto, A. Falcone, M. T. Nobile, B. Parodi, S. Cafaggi, G. Bignardi

Research output: Contribution to journalArticlepeer-review

Abstract

Seven patients with advanced colon cancer, refractory to conventional chemotherapy, and malignant disease confined to the intra-abdominal space received a total of 24 consecutive courses of ip 5-Fluorouracil (5-FU). 5-FU 1000 mg was administered in 2 L of warm (37°C) dialysate daily for five consecutive days every 28 days. 5-FU concentrations in serum, peritoneal fluid and urine were measured by high pressure liquid chromatography (HPLC). The mean disappearance half-life of 5-FU from the peritoneal fluid was 1.6 hours with a mean permeability area product (PA) of 22.4 ml/min. The mean peritoneal AUC was 450±165 times greater than the mean serum AUC. Ip 5-FU treatment is well tolerated, can be safely administered on an outpatient basis and produces a significant pharmacological advantage over conventional routes of administration.

Original languageEnglish
Pages (from-to)829-832
Number of pages4
JournalAnticancer Research
Volume7
Issue number4 B
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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