Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

Jorge Triana; José Luis Eiroa; Juan José Ortega; Francisco León; Ignacio Brouard; Fernando Torres; José Quintana; Francisco Estévez; Jaime Bermejo

doi:10.1021/np800474v

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

Jorge Triana, José Luis Eiroa, Juan José Ortega, Francisco León, Ignacio Brouard, Fernando Torres, José Quintana, Francisco Estévez, Jaime Bermejo

Istituto Clinico Humanitas

Research output: Contribution to journal › Article

Abstract

Four new sesquiterpene lactones (1-4) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549).

Original language	English
Pages (from-to)	2015-2020
Number of pages	6
Journal	Journal of Natural Products
Volume	71
Issue number	12
DOIs	https://doi.org/10.1021/np800474v
Publication status	Published - Dec 26 2008

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ASJC Scopus subject areas

Complementary and alternative medicine
Molecular Medicine
Organic Chemistry
Analytical Chemistry
Pharmaceutical Science
Pharmacology
Drug Discovery

Cite this

Triana, J., Eiroa, J. L., Ortega, J. J., León, F., Brouard, I., Torres, F., Quintana, J., Estévez, F., & Bermejo, J. (2008). Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities. Journal of Natural Products, 71(12), 2015-2020. https://doi.org/10.1021/np800474v

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities. / Triana, Jorge; Eiroa, José Luis; Ortega, Juan José; León, Francisco; Brouard, Ignacio; Torres, Fernando; Quintana, José; Estévez, Francisco; Bermejo, Jaime.

In: Journal of Natural Products, Vol. 71, No. 12, 26.12.2008, p. 2015-2020.

Research output: Contribution to journal › Article

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Access to Document

10.1021/np800474v