Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

Jorge Triana, José Luis Eiroa, Juan José Ortega, Francisco León, Ignacio Brouard, Fernando Torres, José Quintana, Francisco Estévez, Jaime Bermejo

Research output: Contribution to journalArticle

Abstract

Four new sesquiterpene lactones (1-4) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549).

Original languageEnglish
Pages (from-to)2015-2020
Number of pages6
JournalJournal of Natural Products
Volume71
Issue number12
DOIs
Publication statusPublished - Dec 26 2008

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ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Triana, J., Eiroa, J. L., Ortega, J. J., León, F., Brouard, I., Torres, F., Quintana, J., Estévez, F., & Bermejo, J. (2008). Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities. Journal of Natural Products, 71(12), 2015-2020. https://doi.org/10.1021/np800474v