Sestrins as a therapeutic bridge between ros and autophagy in cancer

Miguel Sánchez-álvarez, Raffaele Strippoli, Massimo Donadelli, Alexandr V. Bazhin, Marco Cordani

Research output: Contribution to journalReview articlepeer-review

Abstract

The regulation of Reactive Oxygen Species (ROS) levels and the contribution therein from networks regulating cell metabolism, such as autophagy and the mTOR-dependent nutrient-sensing pathway, constitute major targets for selective therapeutic intervention against several types of tumors, due to their extensive rewiring in cancer cells as compared to healthy cells. Here, we discuss the sestrin family of proteins—homeostatic transducers of oxidative stress, and drivers of antioxidant and metabolic adaptation—as emerging targets for pharmacological intervention. These adaptive regulators lie at the intersection of those two priority nodes of interest in antitumor intervention—ROS control and the regulation of cell metabolism and autophagy—therefore, they hold the potential not only for the development of completely novel compounds, but also for leveraging on synergistic strategies with current options for tumor therapy and classification/stadiation to achieve personalized medicine.

Original languageEnglish
Article number1415
Pages (from-to)1-21
Number of pages21
JournalCancers
Volume11
Issue number10
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Autophagy
  • Cancer therapy
  • Nutrient management
  • ROS
  • Sestrins
  • Stress response

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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