Setting a research agenda for progressive multiple sclerosis

The International Collaborative on Progressive MS

Robert J. Fox, Alan Thompson, David Baker, Peer Baneke, Doug Brown, Paul Browne, Dhia Chandraratna, Olga Ciccarelli, Timothy Coetzee, Giancarlo Comi, Anthony Feinstein, Raj Kapoor, Karen Lee, Marco Salvetti, Kersten Sharrock, Ahmed Toosy, Paola Zaratin, Kim Zuidwijk

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS.

Original languageEnglish
Pages (from-to)1534-1540
Number of pages7
JournalMultiple Sclerosis Journal
Volume18
Issue number11
DOIs
Publication statusPublished - 2012

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Multiple Sclerosis
Research
Therapeutics
Financial Management
Volunteers
Theoretical Models
Rehabilitation
Outcome Assessment (Health Care)
Clinical Trials

Keywords

  • multiple sclerosis
  • neuroprotection
  • progressive multiple sclerosis
  • rehabilitation
  • research agenda

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Fox, R. J., Thompson, A., Baker, D., Baneke, P., Brown, D., Browne, P., ... Zuidwijk, K. (2012). Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS. Multiple Sclerosis Journal, 18(11), 1534-1540. https://doi.org/10.1177/1352458512458169

Setting a research agenda for progressive multiple sclerosis : The International Collaborative on Progressive MS. / Fox, Robert J.; Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim.

In: Multiple Sclerosis Journal, Vol. 18, No. 11, 2012, p. 1534-1540.

Research output: Contribution to journalArticle

Fox, RJ, Thompson, A, Baker, D, Baneke, P, Brown, D, Browne, P, Chandraratna, D, Ciccarelli, O, Coetzee, T, Comi, G, Feinstein, A, Kapoor, R, Lee, K, Salvetti, M, Sharrock, K, Toosy, A, Zaratin, P & Zuidwijk, K 2012, 'Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS', Multiple Sclerosis Journal, vol. 18, no. 11, pp. 1534-1540. https://doi.org/10.1177/1352458512458169
Fox, Robert J. ; Thompson, Alan ; Baker, David ; Baneke, Peer ; Brown, Doug ; Browne, Paul ; Chandraratna, Dhia ; Ciccarelli, Olga ; Coetzee, Timothy ; Comi, Giancarlo ; Feinstein, Anthony ; Kapoor, Raj ; Lee, Karen ; Salvetti, Marco ; Sharrock, Kersten ; Toosy, Ahmed ; Zaratin, Paola ; Zuidwijk, Kim. / Setting a research agenda for progressive multiple sclerosis : The International Collaborative on Progressive MS. In: Multiple Sclerosis Journal. 2012 ; Vol. 18, No. 11. pp. 1534-1540.
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